DETERMINATION OF DOPAMINE AND SEROTONIN WITH IMMUNE STATE CD4 AND CD8 OF THE NEWCASTLE INFECTION IN BROILERS

IF 1.1 Q3 AGRICULTURE, MULTIDISCIPLINARY IRAQI JOURNAL OF AGRICULTURAL SCIENCES Pub Date : 2023-08-29 DOI:10.36103/ijas.v54i4.1785

A. H. Ulaiwi

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Abstract

This study was aimed to describ the course of Newcastle disease at 24 and 72 hr. of infections in broilers flocks within the period (1-December-2021 to 1- Jun- 2022) and the study aimed to determine the immunological (CD4, CD8) response and changes in neurotransmitter hormones. The blood samples were collected and prepared then examined by ELISA kits test and were worked under the protocols of companies. The result of immunological response showed the response to cellular immunity (CD8) in all cases increasing within 24hr.with statistically represented levels while, the result of humoral immunity (CD4) increasing in all cases except two cases within 72hr. with statistically significant levels as well as the results of (CD4/ CD8) ratio. while the results neurotransmitter hormones concentration revealed all cases statistically decreased represented levels at 72hr. The study concluded the 1st immune response within 24hr. showed elevation with cellular immunity then humoral immunity after 48-72hr. Also the ND infections caused down-regulation of neurotransmitter hormones by decreasing to serotonin and dopamine levels during all periods of infections.

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新城感染肉鸡免疫状态cd4和cd8对多巴胺和血清素的影响

本研究旨在描述新城疫在24和72小时的病程。研究期间(2021年12月1日至2022年6月1日)对肉鸡群感染的影响，旨在确定免疫(CD4, CD8)反应和神经递质激素的变化。采集并制备血样，采用酶联免疫吸附试验(ELISA)试剂盒检测，并按公司规程进行处理。免疫应答结果显示，所有病例的细胞免疫应答(CD8)在24hr内升高。而体液免疫结果(CD4)在72小时内除2例外，其余病例均升高。(CD4/ CD8)比值结果均有统计学意义。结果显示，所有病例的神经递质激素浓度在72小时时均有所下降。该研究在24小时内完成了第一次免疫反应。48-72hr后细胞免疫先升高，体液免疫后升高。ND感染引起神经递质激素的下调，在感染的所有时期血清素和多巴胺水平下降。

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来源期刊

IRAQI JOURNAL OF AGRICULTURAL SCIENCES AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

50.00%

发文量

140

审稿时长

6 weeks

期刊介绍： IRAQI JOURNAL OF AGRICULTURAL SCIENCES (IJAS)is the first agric. scientific and refereed journal established in Iraq. The first volume was published in 1966. IJAS is registered in the number 137 in 1988 of the Baghdad National Library. Years ago, it was published with one issue a year. For the time being, it is published bimonthly (6 issues for a volume). IJAS Deal with: Field Crops. Plant Breeding. Agricultural Economics. Agricultural Extension. Agricultural Mechanization. Basic sciences. Hort. Sciences. Animal Husbandry. Food Technology, Plant Pathology. Plant Entomology. Poultry Sciences. Soil Sciences. Water Resources. Veterinary. Biology.