Anticancer effects of vecuronium bromide and cisatracurium besylate on lung cancer cells (A549), in vitro

Biomedicine & Aging Pathology Pub Date : 2014-10-01 DOI:10.1016/j.biomag.2014.07.004

Iddrisu Baba Yabasin , Mohammed Mohammed Ibrahim , Abass Adam , Sam-Awortwi Wilfred , Juventus Benogle Ziem , Peng Gao , Silvanus Kampo , Wen Qingping

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引用次数: 5

Abstract

Neuromuscular blocking drugs are used in anesthesia and intensive care to provide skeletal muscle relaxation. However, literature has revealed that the effects of these drugs on cancer have not been widely studied. We tested the effects of two non-depolarising neuromuscular blocking drugs, vecuronium bromide and cisatracurium besylate on lung cancer cells’ (A549) proliferation, migration and viability in the presence of a cytotoxic drug, cisplatin. We demonstrated in this study that both neuromuscular blocking agents inhibit lung cancer cells’ proliferation. In addition, the study revealed that vecuronium bromide and cisatracurium besylate was synergistic to cisplatin in reducing lung cancer cell proliferation. However, vecuronium inhibits lung cancer cells migration in vitro.

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维库溴铵和顺阿曲库铵对肺癌细胞(A549)的体外抗癌作用

神经肌肉阻断药物用于麻醉和重症监护，以提供骨骼肌放松。然而，文献显示，这些药物对癌症的影响尚未得到广泛研究。我们测试了两种非去极化神经肌肉阻断药物，维库溴铵和顺阿曲库铵在细胞毒性药物顺铂存在下对肺癌细胞(A549)增殖、迁移和活力的影响。我们在这项研究中证明，两种神经肌肉阻滞剂都能抑制肺癌细胞的增殖。此外，本研究还发现维库溴铵和顺阿曲库铵与顺铂在减少肺癌细胞增殖方面具有协同作用。然而，维库溴铵在体外抑制肺癌细胞的迁移。

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Biomedicine & Aging Pathology

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