J. Jumina, Rizky Woro Styaningrum, D. Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, E. N. Sholikhah, A. K. Zulkarnain
{"title":"Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds","authors":"J. Jumina, Rizky Woro Styaningrum, D. Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, E. N. Sholikhah, A. K. Zulkarnain","doi":"10.19261/cjm.2019.624","DOIUrl":null,"url":null,"abstract":"Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions (max= 310-360 nm) and molar absorptivity values (= 14,000-20,000 Mcm). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"6 1","pages":"90-96"},"PeriodicalIF":0.5000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Journal of Moldova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19261/cjm.2019.624","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 6
Abstract
Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions (max= 310-360 nm) and molar absorptivity values (= 14,000-20,000 Mcm). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.
期刊介绍：
"Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry" seeks to publish experimental or theoretical research results of outstanding significance and timeliness in all fields of Chemistry, including Industrial and Ecological Chemistry. The main goal of this edition is strengthening the Chemical Society of Moldova, following development of research in Moldovan chemical institutions and promotion of their collaboration with international chemical community. Manuscripts are welcome from all countries.
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