Induction of adaptive response to chronic environmental and occupational exposure to radiation

I. Kogarko, A. Akleev, V. Petushkova, Е.А. Neyfakh, B. Kogarko, O. V. Ktitorova, I. Ganeev
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引用次数: 1

Abstract

The paper summarizes results of medical examination of two groups of patients, the public members resided in high natural background radiation areas and occupationally irradiated nu-clear and health workers. Adaptive response to chronic exposure to radiation was found to last much time and, thus, its impact on the development of late health effects, including cancer, may be great. In vitro studies demonstrate that induction of adaptive response is the multistep process including the excision reparation of nucleotides, nonhomologous DNA ends joining, antioxidative system and cell cycle control factors. The review presents data on effects of low doses radiation of high or low relative radiation effectiveness(RBE). Some damaged peripheral blood lympho-cytes demonstrated increased radioresistance to high radiation doses, results of examinations of both the public members and professionals.
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诱导对慢性环境和职业辐射暴露的适应性反应
本文总结了两组患者、居住在高本底辐射地区的公众和受职业辐射的核卫生工作者的医学检查结果。研究发现,对慢性辐射照射的适应性反应持续很长时间,因此,它对包括癌症在内的后期健康影响的发展影响可能很大。体外研究表明,适应性反应的诱导是一个多步骤的过程,包括核苷酸的切除修复、非同源DNA末端的连接、抗氧化系统和细胞周期控制因素。这篇综述介绍了低剂量辐射对高或低相对辐射效能(RBE)的影响的数据。一些受损的外周血淋巴细胞对高辐射剂量的抗辐射能力增强,这是公众成员和专业人员检查的结果。
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