Kombinierte Immunsuppression mit Vincristinsulfat and Cyclophosphamid

J.A. Schwarz , G. Harbauer, R. Hofmann, H.-J. Wilhelm, H. Lutz
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Abstract

Following immunization against sheep erythrozytes, it is possible to induce a double-peaked antibody response curve in the serum of experimental animals (rats) by using vincristine sulfate (Vi). Immunosuppression is enhanced in thymectomised and sensitised animals during rechallenge following Vi/Cy, as compaired to animals treated with cyclophosphamide (Cy) alone, and an attenuated anamnestic reaction is subsequently observed.

Survival time of allogeneic skin grafts in colony bred and inbred rat strains could not be prolonged by using Vi/Cy, as compaired to animals treated with Cy alone.

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水里有抑制免疫的作用
在绵羊红细胞免疫后,使用硫酸长春新碱(Vi)可以在实验动物(大鼠)的血清中诱导双峰抗体反应曲线。与单独使用环磷酰胺(Cy)处理的动物相比,在Vi/Cy后再挑战时,胸腺去核和致敏动物的免疫抑制增强,随后观察到减轻的记忆反应。与单独使用Cy相比,使用Vi/Cy不能延长群体繁殖和自交系大鼠同种异体植皮的存活时间。
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