Cancer Chemopreventive Property of Bidens pilosa Methanolic Extract on Two Stage in vivo Skin Carcinogenesis Model

Abstract

Bidens pilosa (Asteraceae) is widely grown throughout in India. The effects of different doses (200 and 400 mg/kg of body weight) of methanolic extract of the whole plant was on drug metabolizing Phase-I and Phase-II enzymes, antioxidant enzymes, lactate dehydrogenase, and lipid peroxidation in the liver of 7-week-old nude/nude mice was studied. In addition, the anticarcinogenic potential of both the plants extract was studied, using the model of DMBA induced forestomach and TPA promoted skin papillomagenesis. Primary findings reveal its potential to induce the Phase-II enzyme activity associated mainly with carcinogen detoxification in liver of mice. The hepatic GST (P and DTD specific activities (P and in extrahepatic organs (from P inhibition of tumor burden, in both the tumor model system studied (P Key words: Bidens pilosa , chemopreventive, DT-diaphorase, glutathione, S-transferase, lactate dehydrogenase.