Towards high sensitive label free DNA detection in lab-on-chip systems

Abstract

Surprisingly high sensitivity for DNA fragment detection in contactless conductivity measurements by capacitive coupling of HF signals into microfluidic channels was further investigated by impedance spectroscopy. Experimental results indicate the general high conductivity with reduced capacitive behaviour in parallel. It can be also influenced by an electrical DC field inducing DNA alignment in the electrical measuring cell. The results encourage further development of electrical detection methods alternatively to sophisticated and expensive optical detection methods.