Research activities on novel drug delivery systems of astatine nanoparticles in human gum cancer cells, tissues and tumors treatment under synchrotron radiation
{"title":"Research activities on novel drug delivery systems of astatine nanoparticles in human gum cancer cells, tissues and tumors treatment under synchrotron radiation","authors":"A. Heidari, K. Schmitt, M. Henderson, E. Besana","doi":"10.15761/DOMR.1000345","DOIUrl":null,"url":null,"abstract":"In the current study, thermoplasmonic characteristics of Astatine nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Astatine nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Astatine nanoparticles by solving heat equation. The obtained results show that Astatine nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"56 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dental, Oral and Maxillofacial Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/DOMR.1000345","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
In the current study, thermoplasmonic characteristics of Astatine nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Astatine nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Astatine nanoparticles by solving heat equation. The obtained results show that Astatine nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.
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