Paper-based microfluidic devices: Fabrication, detection, and significant applications in various fields

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2022-01-01 DOI:10.1515/revac-2022-0037
S. Das, Gagandeep, R. Bhatia
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引用次数: 17

Abstract

Abstract Paper is the most abundant and inexpensive polymeric structure of cellulose available. Paper has micro-porous capillary-like networks which are responsible for flow of solvents instead of pumps or electronic power, making paper an ideally usable tool. Microfluidic paper-based analytical devices use fabricated paper devices on which hydrophilic zones are formed within hydrophobic barriers. Hydrophilic zones act as regions for actual analytical purposes, whereas hydrophobic zones act to demarcate separate zones from one another. Clinically, these devices have been proved to be excellent point-of-care-devices in diagnosis which can bypass use of costly and time-consuming laboratory techniques. In the presented review, the basic principles and components involved in the design of paper-based devices were then summarised in understandable manner. Further, various applications in different fields were also compiled in the form of text under different sections and tables. Paper-based analytical devices may serve as an excellent tool in variety of analytical works as these techniques are simple, rapid, economic, and require less human power or trainings. They have prominent applications in analysis of biological fluids, drugs/metabolites, food stuffs, colorants, biomarkers, and several other fields.
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纸基微流控装置:制造、检测及在各领域的重要应用
纸是纤维素中含量最丰富、价格最低廉的聚合物结构。纸具有微孔的毛细管状网络,它负责溶剂的流动,而不是泵或电子电源,使纸成为理想的可用工具。微流控纸基分析装置使用制备的纸装置,其亲水性区域在疏水屏障内形成。亲水区作为实际分析目的的区域,而疏水区作为彼此分开的区域。在临床上,这些设备已被证明是诊断中出色的护理点设备,可以绕过使用昂贵和耗时的实验室技术。在提出的审查,基本原则和组成部分所涉及的设计的纸为基础的设备,然后总结在可理解的方式。此外,还在不同的章节和表格下以文本的形式汇编了不同领域的各种申请。基于纸张的分析设备由于其简单、快速、经济、不需要人力或培训等优点,可以作为各种分析工作的优秀工具。它们在生物流体、药物/代谢物、食品、着色剂、生物标志物和其他几个领域的分析中有着突出的应用。
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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