Lifestyle factors and insulin-like growth factor 1 levels among elderly men.

L. Signorello, H. Kuper, P. Lagiou, J. Wuu, L. Mucci, D. Trichopoulos, H. Adami
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引用次数: 52

Abstract

Insulin-like growth factor 1 (IGF-1) is a potentially important determinant of disease; hence epidemiological identification of factors that influence circulating IGF-1 is merited. We therefore analysed data collected in Greece to determine the relationship between anthropometric, lifestyle and dietary variables and serum levels of IGF-1 among elderly men. We identified 51 men with prostate cancer, 50 men with benign prostatic hyperplasia, and 52 apparently healthy elderly men (controls), all matched for age (+/- 1 year). These 153 men provided blood specimens and were interviewed using a validated lifestyle and food frequency questionnaire. We performed multivariate linear regression to identify potential predictors of circulating IGF-1. After controlling for age, body mass index, smoking habits, alcohol drinking and coffee consumption, each 5 cm increase in height predicted a 13.0% increase in IGF-1 (95% CI 0.4-27.2%) among the controls and a 11.3% increase in IGF-1 (95% CI 4.5-18.6%) among the entire study group. None of the investigated dietary factors (total fat, carbohydrate, protein, dairy products, tomatoes, calcium) were strongly related to IGF-1 levels. The positive association between IGF-1 and height integrates the empirical evidence linking IGF-1 and height with prostate cancer risk.
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老年男性生活方式因素与胰岛素样生长因子1水平的关系
胰岛素样生长因子1 (IGF-1)是疾病的潜在重要决定因素;因此,有必要对影响循环IGF-1的因素进行流行病学鉴定。因此,我们分析了在希腊收集的数据,以确定老年男性中人体测量、生活方式和饮食变量与血清IGF-1水平之间的关系。我们确定了51名前列腺癌男性,50名良性前列腺增生男性和52名明显健康的老年男性(对照组),所有年龄匹配(±1岁)。这153名男性提供了血液样本,并使用有效的生活方式和食物频率问卷进行了访谈。我们采用多元线性回归来确定循环IGF-1的潜在预测因子。在控制了年龄、体重指数、吸烟习惯、饮酒和喝咖啡等因素后,身高每增加5厘米,对照组中IGF-1水平增加13.0% (95% CI 0.4-27.2%),整个研究组中IGF-1水平增加11.3% (95% CI 4.5-18.6%)。所有被调查的饮食因素(总脂肪、碳水化合物、蛋白质、乳制品、西红柿、钙)都与IGF-1水平没有密切关系。IGF-1和身高之间的正相关整合了将IGF-1和身高与前列腺癌风险联系起来的经验证据。
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