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The PROPHET project paves the way for personalized prevention in the future healthcare. PROPHET 项目为未来医疗保健的个性化预防铺平了道路。
R. Pastorino, A. M. Pezzullo, T. Osti, Róza Ádány, Pascal Borry, F. Barnhoorn, Eva Fadil, Mark Kroese, A. Metspalu, Beatriz Perez-Gomez, M. Perola, Daniela Quaggia, S. Scollen, Mahsa Shabani, Stefan Swartling Peterson, C. van El, Astrid Vicente, S. Boccia
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引用次数: 0
Cancer mortality predictions for 2024 in selected Asian countries and Australia with focus on stomach cancer. 2024 年部分亚洲国家和澳大利亚的癌症死亡率预测,重点是胃癌。
C. Santucci, S. Mignozzi, F. Levi, M. Malvezzi, P. Bertuccio, A. Odone, M. C. Camargo, C. La Vecchia, Eva Negri
INTRODUCTIONWe estimated cancer mortality figures in five major Asian countries and Australia for 2024, focusing on stomach cancer, a leading cause of cancer-related deaths in Eastern Asia.METHODSWe computed country- and sex-specific annual age-standardized rates (ASRs) for total cancers and the 10 most common cancer sites, using WHO and the United Nations Population Division databases from 1970 to 2021 or the latest available year. We predicted figures for 2024 and estimated the number of avoided cancer deaths in 1994-2024.RESULTSAll cancers combined ASR declined between 2015-2019 and 2024 across considered countries and sexes. In 2024, the lowest predicted male rate is in the Philippines (75.0/100 000) and the highest in Australia (94.2/100 000). The Republic of Korea is predicted to have the lowest female ASR (42.1/100 000) while the Philippines the highest (74.5/100 000). Over the last three decades, 121 300 deaths were estimated to be avoided in Hong Kong SAR, 69 500 in Israel, 1 246 300 in Japan, 653 300 in the Republic of Korea, 303 300 in Australia, and 89 700 among Philippine men. Mortality from stomach cancer has been decreasing since 1970 in all considered countries and both sexes. Significant decreases are at all age groups Male rates remain, however, high in Japan (8.7/100 000) and the Republic of Korea (6.2/100 000).CONCLUSIONDeclining cancer mortality is predicted in the considered countries, notably reducing stomach cancer burden. Stomach cancer, however, remains a major public health issue in East Asia.
方法我们利用世界卫生组织和联合国人口司 1970 年至 2021 年或最近一年的数据库,计算了各国和各性别总癌症和 10 个最常见癌症部位的年度年龄标准化比率(ASRs)。我们预测了 2024 年的数字,并估算了 1994-2024 年间避免的癌症死亡人数。预测 2024 年男性死亡率最低的国家是菲律宾(75.0/100000),最高的国家是澳大利亚(94.2/100000)。预计大韩民国的女性 ASR 最低(42.1/100000),而菲律宾最高(74.5/100000)。在过去三十年中,香港特别行政区估计可避免 121 300 例死亡,以色列为 69 500 例,日本为 1 246 300 例,大韩民国为 653 300 例,澳大利亚为 303 300 例,菲律宾男性为 89 700 例。自 1970 年以来,所有国家的男女胃癌死亡率都在下降。所有年龄组的死亡率都有显著下降,但日本(8.7/100 000)和大韩民国(6.2/100 000)的男性死亡率仍然较高。然而,胃癌仍然是东亚的一个主要公共卫生问题。
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引用次数: 0
Prostate cancer burden in major BRICS countries, 1990-2019: findings from the 2019 global burden of disease study. 1990-2019年金砖五国主要国家的前列腺癌负担:2019年全球疾病负担研究结果。
Juan Zhang, Juanjuan Ma, Shuting Li, Yan Ma
BACKGROUNDThis study assessed prostate cancer burden and trends in major BRICS countries (Brazil, Russia, India, China, and South Africa) from 1990 to 2019.METHODSUtilizing Global Burden of Disease Study 2019 data, we calculated age-standardized rates for prostate cancer incidence, prevalence, mortality, and disability-adjusted life years (DALYs) with 95% uncertainty intervals (UIs). Joinpoint regression analysis determined the average annual percentage change (AAPC) for trend characterization.RESULTSProstate cancer ranked highest in China for incidence, prevalence, mortality, and DALYs. In 2019, Brazil had the highest age-standardized incidence rate (ASIR) [55.029 (95% UI: 47.744-81.831)] and age-standardized prevalence rate (ASPR) [372.511 (95% UI: 327.549-549.128)], while South Africa recorded the highest age-standardized mortality rate (ASMR) [42.241 (95% UI: 32.146-47.933)], and age-standardized DALY rate (ASDR) [666.085 (95% UI: 522.626-764.612)]. ASIR and ASPR increased significantly over three decades (AAPC > 0), with varying ASMR and ASDR trends.CONCLUSIONProstate cancer poses a significant public health challenge. While incidence and prevalence rise, mortality declines in China, India, and Brazil. Tailored health policies are crucial to address diverse disease burden characteristics.
背景本研究评估了 1990 年至 2019 年主要金砖国家(巴西、俄罗斯、印度、中国和南非)的前列腺癌负担和趋势。方法利用 2019 年全球疾病负担研究数据,我们计算了前列腺癌发病率、流行率、死亡率和残疾调整寿命年数(DALYs)的年龄标准化率,以及 95% 的不确定区间(UIs)。结果前列腺癌在中国的发病率、患病率、死亡率和残疾调整寿命年数均居首位。2019年,巴西的年龄标准化发病率(ASIR)[55.029(95% UI:47.744-81.831)]和年龄标准化患病率(ASPR)[372.511(95% UI:327.549-549.南非的年龄标准化死亡率(ASMR)[42.241(95% UI:32.146-47.933)]和年龄标准化残疾调整寿命年率(ASDR)[666.085(95% UI:522.626-764.612)]最高。]三十年来,ASIR 和 ASPR 显著增加(AAPC > 0),ASMR 和 ASDR 的趋势各不相同。在中国、印度和巴西,虽然发病率和患病率上升,但死亡率却在下降。针对不同的疾病负担特点,制定有针对性的卫生政策至关重要。
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引用次数: 0
Non-contrast MRI and post-mastectomy silicone breast implant rupture: preventing false positive diagnoses. 非对比核磁共振成像与乳房切除术后硅胶乳房假体破裂:防止假阳性诊断。
Luca Mazzocconi, Francesca De Lorenzi, Riccardo Carbonaro, Valerio Lorenzano, A. Rotili, F. Pesapane, G. Signorelli, Pietro Caldarella, Giovanni Corso, Enrico Cassano, Paolo Veronesi
BACKGROUNDBreast implants are not lifelong, with implant rupture being the third leading cause of revisional surgery in augmented women. Noncontrast MRI is a reliable tool to assess implant integrity; however, false positive and false negative diagnoses have been reported due to an incorrect interpretation of MRI signs. This study aims to investigate the incidence of these misleading results, comparing MRI findings with intraoperative surgical observations and exploring signs of nonunivocal interpretation.MATERIALS AND METHODSBetween March 2019 and October 2022, our hospital, a referral center for breast cancer care, conducted 139 breast MRI examinations to evaluate implant integrity. Surgical intervention was deemed necessary for patients diagnosed with suspected or confirmed implant rupture at MRI. Those patients who did not undergo any surgical procedure (63 cases) or had surgery at different institutes (11 cases) were excluded.RESULTSAmong the 65 patients who underwent preoperative MRI and subsequent surgery at our institute, surgical findings confirmed the preoperative MRI diagnosis in 48 women. Notably, 17 women exhibited a discordance between MRI and surgical findings: three false negatives, 11 false positives and three possible ruptures not confirmed. Signs of nonunivocal or misleading interpretation were assessed on a patient-by-patient basis. The importance of obtaining detailed information about a patient's breast implant, including fill materials, number of lumens, manufacturer and shape, proved immensely beneficial for interpreting MRI signs accurately.CONCLUSIONPre-MRI knowledge of implant details and a meticulous evaluation of non-univocal signs can aid radiologists in accurately assessing implant integrity, reducing the risk of unnecessary revisional surgeries, and potentially averting allegations of medical malpractice.
背景乳房假体并非终生植入,假体破裂是隆胸女性接受翻修手术的第三大原因。非对比核磁共振成像是评估假体完整性的可靠工具;但也有报道称,由于对核磁共振成像征象的错误解读,导致假阳性和假阴性诊断。本研究旨在调查这些误导性结果的发生率,比较核磁共振成像结果与术中手术观察结果,并探讨非明确解释的迹象。材料和方法2019 年 3 月至 2022 年 10 月期间,我院作为乳腺癌护理转诊中心,进行了 139 次乳腺核磁共振成像检查,以评估植入物的完整性。经核磁共振检查诊断为疑似或确诊假体破裂的患者必须接受手术治疗。结果在接受术前磁共振成像检查并随后在我院接受手术的 65 名患者中,有 48 名女性的手术结果证实了术前磁共振成像诊断。值得注意的是,有 17 名妇女的核磁共振成像和手术结果不一致:3 例假阴性、11 例假阳性和 3 例未证实的可能破裂。不明确或误导性解释的迹象是根据患者的具体情况进行评估的。事实证明,获得患者乳房假体的详细信息(包括填充材料、腔隙数量、制造商和形状)对于准确解释核磁共振成像征象非常重要。结论 在进行核磁共振成像前了解假体的详细信息并对非明确征象进行细致评估,有助于放射科医生准确评估假体的完整性,降低不必要的翻修手术风险,并有可能避免医疗事故指控。
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引用次数: 0
Comment to: Inequalities in adherence to cervical cancer screening in Portugal. 评论:葡萄牙坚持宫颈癌筛查的不平等。
Réka Mihály-Vajda, T. Csákvári, D. Pónusz-Kovács, V. Varga, Fanni Luca Kajos, I. Boncz
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引用次数: 0
Response to the letter to the editor by Weberpals et al. on our article entitled 'β-Blocker use and mortality in cancer patients: systematic review and meta-analysis of observational studies'. 回复Weberpals等人就我们题为“癌症患者β受体阻滞剂的使用和死亡率:观察性研究的系统回顾和荟萃分析”的文章致编辑的信。
Shanliang Zhong, Jian-hua Zhao
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引用次数: 1
Gastric cancer mortality in a high-incidence area (Ardabil Province, Northwest Iran): What risk factors are causative? 高发病率地区(伊朗西北部阿达比尔省)胃癌死亡率:哪些危险因素是致病因素?
H. Leylabadlo, H. Kafil, M. Yousefi
(RET)/papillary thyroid carcinoma (PTC) rearrangements in radiation-induced thyroid cancer was mainly identified from post-Chernobyl tumors, which resulted from extremely high dose radiation exposure (Nikiforova et al., 2004). Chernobyl-related radiation-induced RET/ PTC rearrangements were also associated with more aggressive tumor behavior (Rabes et al., 2000). However, no clear evidence has shown that low-dose radiation exposure through medical practice induces RET/PTC rearrangements. Although Seaberg et al. (2009) found that ionizing radiation exposure resulting from various sources was associated with more aggressive tumor pathology, this relationship is still inconclusive (Furlan and Rosen, 2004; Seaberg et al., 2009). Our study did not find diagnostic radiography to be associated with multifocal disease and lymph node involvement.
(RET)/乳头状甲状腺癌(PTC)在辐射诱发甲状腺癌中的重排主要发现于切尔诺贝利后的肿瘤,这是由于极高剂量的辐射暴露造成的(Nikiforova et al., 2004)。切尔诺贝利相关辐射诱发的RET/ PTC重排也与更具侵袭性的肿瘤行为相关(Rabes et al., 2000)。然而,没有明确的证据表明,通过医疗实践的低剂量辐射暴露会导致RET/PTC重排。尽管Seaberg等人(2009)发现,来自各种来源的电离辐射暴露与更具侵袭性的肿瘤病理有关,但这种关系仍然没有定论(Furlan和Rosen, 2004;Seaberg et al., 2009)。我们的研究没有发现诊断性影像学检查与多灶性疾病和淋巴结受累有关。
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引用次数: 16
Response to the commentary letter entitled 'Diagnostic radiography and thyroid cancer - causation or simply an association?' to our article entitled 'Diagnostic radiography exposure increases the risk for thyroid microcarcinoma: a population-based case-control study' that was published in the Europe 对题为“诊断放射摄影和甲状腺癌——是因果关系还是仅仅是一种关联?”的评论信的回应?在欧洲发表的题为“诊断性放射照相暴露增加甲状腺微癌的风险:一项基于人群的病例对照研究”的文章中
Yawei Zhang, Huang Huang, Jason E. Sandler, R. Udelsman
Our study population included incident thyroid cancer patients who were diagnosed with papillary (84.8%), follicular (12.1%), medullary (2.6%), anaplastic (0.2%), or other thyroid cancers (0.2%). Well-differentiated thyroid cancers included both papillary and follicular thyroid cancer cases; they accounted for 96.9% of all cases. We had limited statistical power to analyze the data for medullary and anaplastic thyroid cancer subtypes. We agree with the comment by Dr Wiltshire and Dr Balasubramanian that our study results can only speak for well-differentiated thyroid cancers. Future studies with sufficient statistical power are needed to investigate whether diagnostic radiography is associated with other thyroid cancers (namely, medullary and anaplastic cancers).
我们的研究人群包括被诊断为乳头状(84.8%)、滤泡状(12.1%)、髓样(2.6%)、间变性(0.2%)或其他甲状腺癌(0.2%)的甲状腺癌患者。分化良好的甲状腺癌包括乳头状癌和滤泡性甲状腺癌;占全部病例的96.9%。我们对髓样和间变性甲状腺癌亚型的数据分析的统计能力有限。我们同意Wiltshire博士和Balasubramanian博士的评论,即我们的研究结果只能说明分化良好的甲状腺癌。未来需要有足够统计能力的研究来调查放射诊断是否与其他甲状腺癌(即髓样癌和间变性癌)相关。
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引用次数: 1
Skin cancer prevention. 预防皮肤癌。
R. Greinert
Skin cancer is for a large extend a preventable disease. In the first place by reduction of risk exposure and secondly by early detection followed by appropriate treatment of this disease. It is therefore that the Committee of High Level European Cancer Experts made already in 1988 a specific recommendation in the European Code against Cancer on the prevention of skin cancer i.e. to avoid excessive exposure of sunlight. This European Code against Cancer is made up of 10 specific recommendations to prevent cancer and is the basis of the European Commission action programme “Europe against Cancer”. Each year, one out of the ten recommendations is highlighted by a large European information campaign directed to the general public and medical professionals. In 1996, the focus of this media campaign is UV-radiation and skin cancer.
皮肤癌在很大程度上是一种可预防的疾病。首先是减少风险暴露,其次是及早发现并适当治疗这种疾病。因此,欧洲高级别癌症专家委员会已于1988年在《欧洲防癌法典》中提出了一项关于预防皮肤癌的具体建议,即避免过度暴露在阳光下。《欧洲防癌守则》由10项预防癌症的具体建议组成,是欧洲委员会“欧洲防癌”行动方案的基础。每年,针对普通公众和医疗专业人员的大型欧洲宣传运动都会强调十项建议中的一项。1996年,这次媒体宣传活动的重点是紫外线辐射和皮肤癌。
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引用次数: 3
Epidemiology of male breast cancer. 男性乳腺癌的流行病学。
F. Levi, F. Lucchini, C. la Vecchia
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引用次数: 11
期刊
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
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