{"title":"Galectin-3: multiple clinical applications","authors":"A. Kisheva, Y. Yotov","doi":"10.14748/bmr.v30.6389","DOIUrl":null,"url":null,"abstract":"Galectin-3 is a β-galactoside binding lectin, containing carbohydrate-recognition domain, which interacts with a number of ligands. It is found in many tissues and is distributed intra– and extracellularly. The localization of the biomarker determines its function. Galectin-3 is involved in variety of biological processes sush as inflammation, fibrosis, immunological response and neoplastic growth. It may be used as a diagnostic or prognostic biomarker especially in cancer and cardiovascular diseases. The present review summarizes some of the properties of this biomarker. Biomed Rev 2019;30:83-88","PeriodicalId":8906,"journal":{"name":"Biomedical Reviews","volume":"38 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14748/bmr.v30.6389","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Galectin-3 is a β-galactoside binding lectin, containing carbohydrate-recognition domain, which interacts with a number of ligands. It is found in many tissues and is distributed intra– and extracellularly. The localization of the biomarker determines its function. Galectin-3 is involved in variety of biological processes sush as inflammation, fibrosis, immunological response and neoplastic growth. It may be used as a diagnostic or prognostic biomarker especially in cancer and cardiovascular diseases. The present review summarizes some of the properties of this biomarker. Biomed Rev 2019;30:83-88
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