Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population

Abstract

To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.