RME-based pharmacology: The inhibition of viral entry as therapeutic perspective in viral diseases including AIDS. Hypothesis updated and enlarged

Abstract

coated pits/vesicles was the best-characterized endocytic pathway. Since then now, intensive research on the mechanisms of both RME and receptor-mediated virus-cell fusion (receptor-mediated fusion - RMF) helped to expand the list of chemical compounds with potential clinical application as antiviral agents, the so-called entry inhibitors, e.g. (i) inhibitors of clathrin-, dynamin-2-, caveolin- and/or lipid rafts-dependent RME, and (ii) inhibitors of RMF. Accordingly, in the present Dance Round we update and enlarge our hypothesis of RME-based antiviral pharmacology. Biomed Rev 2018; 29: 109-118