Preparation and Characterization of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique

Abstract

The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO) technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.