S. Azam, Hassan Eliwan, Fatima Eltayeb Hago, A. Hammoudi
{"title":"Neupogen (Filgrastim) Induced Acute Hematuria/Proteinuria with 3 Days of Use in a 7-Year-old Boy Diagnosed as Aplastic Anemia","authors":"S. Azam, Hassan Eliwan, Fatima Eltayeb Hago, A. Hammoudi","doi":"10.2991/dsahmj.k.200704.001","DOIUrl":null,"url":null,"abstract":"Filgrastim is a recombinant human Granulocyte Colony-stimulating Factor (G-CSF) approved by the US Food and Drug Administration [1]. It is used to treat patients with neutropenia caused by chemotherapy [2–5], human immunodeficiency virus infection [6], bone marrow transplant [7–9], or in cases of congenital [2,7], cyclic [2,10], or idiopathic neutropenias [2,11]. It is a hematopoietic growth factor that influences leukopoiesis [12–14], and affects the proliferation and differentiation of neutrophils within the bone marrow [15,16] and possibly other sites (e.g., spleen) [17,18]. It binds directly to G-CSF receptors on neutrophil progenitor target cell surfaces [19,20] and stimulates neutrophil proliferation, thereby increasing neutrophil counts and activity [21,22].","PeriodicalId":52781,"journal":{"name":"Dr Sulaiman Al Habib Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dr Sulaiman Al Habib Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2991/dsahmj.k.200704.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Filgrastim is a recombinant human Granulocyte Colony-stimulating Factor (G-CSF) approved by the US Food and Drug Administration [1]. It is used to treat patients with neutropenia caused by chemotherapy [2–5], human immunodeficiency virus infection [6], bone marrow transplant [7–9], or in cases of congenital [2,7], cyclic [2,10], or idiopathic neutropenias [2,11]. It is a hematopoietic growth factor that influences leukopoiesis [12–14], and affects the proliferation and differentiation of neutrophils within the bone marrow [15,16] and possibly other sites (e.g., spleen) [17,18]. It binds directly to G-CSF receptors on neutrophil progenitor target cell surfaces [19,20] and stimulates neutrophil proliferation, thereby increasing neutrophil counts and activity [21,22].