The roles of micro RNA in pancreas development and regeneration

Tamara I Rabe, Farnaz Shamsi, A. Mansouri
{"title":"The roles of micro RNA in pancreas development and regeneration","authors":"Tamara I Rabe, Farnaz Shamsi, A. Mansouri","doi":"10.14748/BMR.V24.22","DOIUrl":null,"url":null,"abstract":"Presence of sufficient number of functional glucose responsive β-cells is indispensable for normal glucose homeostasis. Diabetes mellitus is a chronic disease associated with loss or reduction of β-cell mass and not β-cell mass. MicroRNAs are small non-coding RNAs that are involved in different biological processes including development, cell proliferation, stress response, and tumor pathogenesis. MicroRNAs fine-tune the gene expression level post-transcriptionally either by mRNA degradation or translational repression. In the past few years, several miRNAs have been introduced as new critical players for pancreas development, function, and regeneration. Deregulation of several microRNAs is found in animal models of diabetes, as well as in diabetic patients. Therefore, it is essential to understand the roles of these microRNAs in β-cell generation and physiology, as well as the biological consequences of their functional impairment. Biomedical Reviews 2013; 24: 57-65.","PeriodicalId":8906,"journal":{"name":"Biomedical Reviews","volume":"8 1","pages":"57-64"},"PeriodicalIF":0.0000,"publicationDate":"2013-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14748/BMR.V24.22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Presence of sufficient number of functional glucose responsive β-cells is indispensable for normal glucose homeostasis. Diabetes mellitus is a chronic disease associated with loss or reduction of β-cell mass and not β-cell mass. MicroRNAs are small non-coding RNAs that are involved in different biological processes including development, cell proliferation, stress response, and tumor pathogenesis. MicroRNAs fine-tune the gene expression level post-transcriptionally either by mRNA degradation or translational repression. In the past few years, several miRNAs have been introduced as new critical players for pancreas development, function, and regeneration. Deregulation of several microRNAs is found in animal models of diabetes, as well as in diabetic patients. Therefore, it is essential to understand the roles of these microRNAs in β-cell generation and physiology, as well as the biological consequences of their functional impairment. Biomedical Reviews 2013; 24: 57-65.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
微RNA在胰腺发育和再生中的作用
足够数量的功能性葡萄糖反应β细胞的存在对于正常的葡萄糖稳态是必不可少的。糖尿病是一种慢性疾病,与β细胞团块的丢失或减少有关,而不是β细胞团块。MicroRNAs是一种小的非编码rna,参与不同的生物学过程,包括发育、细胞增殖、应激反应和肿瘤发病。MicroRNAs在转录后通过mRNA降解或翻译抑制来微调基因表达水平。在过去的几年中,一些mirna作为胰腺发育、功能和再生的新关键参与者被引入。在糖尿病动物模型和糖尿病患者中发现了几种microrna的失调。因此,有必要了解这些microrna在β细胞生成和生理中的作用,以及它们的功能损伤的生物学后果。生物医学评论2013;24: 57 - 65。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Role of NANOG in glioma malignancy development and potential as therapeutic target A sample copy of the textbook Principles of Cell and Tissue Biology In defense of the murburn explanation for aerobic respiration The great Geoffrey Burnstock: A passion for discovery and empathy On the new prospects in biology inspired by epigenetics
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1