SYNTHESIS, CHARACTERIZATION AND ANTICONVULSANT ACTIVITY OF SOME PYRAZOLE DERIVATIVES

Abstract

A several number of novel 4-(aryl/substituted aryl)-1-(unsubstituted/aryl/substituted aryl)-3-phenyl-1H-pyrazoles have been synthesized by the reaction of 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones and appropriate unsubstituted and substituted hydrazine in ethanol. 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones were synthesized by the bromination of 1-substituted phenyl-3-phenyl-prop-2-en-1-ones which were synthesized by the reaction of acetophenone with appropriate unsubstituted and substituted aromatic aldehyde. The synthesized compounds were confirmed by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The anticonvulsant activity of the synthesized compounds has indicated that all the compounds significantly reduce the electro shock induced convulsions, compared to phenytoin. The pharmacological evaluation may be concluded that the replacement of 1H position of pyrazole with phenyl and substituted phenyl increases the anticonvulsant activity.