{"title":"Stirring and electric field assisted microbubble preparation","authors":"H. Zhang, J. Li","doi":"10.1179/175889709X12615681946485","DOIUrl":null,"url":null,"abstract":"AbstractIn this paper, a stirring and electric field assisted microbubble preparation (SEFAMP) method for the preparation of microbubble ultrasound contrast agents is reported. Microbubbles with a narrow size distribution were obtained. The coalescence of microbubbles, which often happens in the stirring method, was eliminated. Addition of polyethylene glycol (PEG) 400 further optimised microbubble size distribution profile. This new method shed a light on realising the microbubble ultrasound agents as drug delivery vehicle and gene therapy for a potential clinical use.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"13 1","pages":"9-15"},"PeriodicalIF":0.0000,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bubble science engineering and technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1179/175889709X12615681946485","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
AbstractIn this paper, a stirring and electric field assisted microbubble preparation (SEFAMP) method for the preparation of microbubble ultrasound contrast agents is reported. Microbubbles with a narrow size distribution were obtained. The coalescence of microbubbles, which often happens in the stirring method, was eliminated. Addition of polyethylene glycol (PEG) 400 further optimised microbubble size distribution profile. This new method shed a light on realising the microbubble ultrasound agents as drug delivery vehicle and gene therapy for a potential clinical use.
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