Detection of carbapenem resistant enterobacteriaceae from various clinical samples: A record based study in a tertiary care hospital in Mandya

Roopa Shree S
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Abstract

: Carbapenem Resistant Enterobacteriaceae (CRE) has gradually evolved as one of the serious global health concern due to its high mortality and limited treatment options. Overuse of the antibiotic and improper sanitation has led to its rapid spread. To determine the proportion of Carbapenem resistant Enterobacteriaceae from various clinical samples received in the Department of Microbiology, MIMS Mandya for Culture and sensitivity by using Meropenem and Imipenem disk.This is a retrospective study conducted over a period of 6 months from March 2021 to august 2021. The samples tested were all the clinical specimens like sputum, pus, urine, body fluids coming to our Microbiology laboratory. The specimens were processed by the standard laboratory methods. Bacteria was isolated and identified by standard biochemical reactions and antimicrobial susceptibility testing was done on Mueller Hinton Agar by Kirby Bauer disk diffusion method and interpreted according to CLSI guidelines.A total of 1624 samples were included in the study, among which 211 isolates were identified as members of Enterobacteriaceae family. 50 out of 211 isolates were confirmed as Carbapenem resistant giving a prevalence rate of 23.69%. Urine (42%) was the major contributor of CRE, followed by pus (34%). Among CRE, (54%) was the major organism isolated followed by (20%).Our study showed high CRE prevalence rate of 23.69%, indicating the rapid emergence of CRE. Hence, a strict adherence to antibiotic policy and basic infection control measures to be applied in view of reducing the spread of CRE in the community.
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从各种临床样本检测耐碳青霉烯类肠杆菌科:在曼迪亚三级保健医院的记录为基础的研究
碳青霉烯耐药肠杆菌科(CRE)由于其高死亡率和有限的治疗选择,已逐渐发展成为严重的全球健康问题之一。抗生素的过度使用和不适当的卫生设施导致了它的迅速传播。目的:采用美罗培南和亚胺培南圆盘检测临床样品中碳青霉烯耐药肠杆菌科菌的比例及敏感性。这是一项为期6个月的回顾性研究,从2021年3月到2021年8月。检测的样本为所有送到微生物实验室的痰、脓、尿、体液等临床标本。样品采用标准实验室方法处理。采用标准生化反应对细菌进行分离鉴定,采用Kirby Bauer圆盘扩散法对Mueller Hinton琼脂进行药敏试验,并按照CLSI指南进行解释。本研究共纳入1624份样本,其中211株分离物为肠杆菌科。211株中有50株对碳青霉烯类耐药,患病率为23.69%。尿液(42%)是CRE的主要来源,其次是脓(34%)。CRE中分离的主要微生物为(54%),其次为(20%)。我们的研究显示,CRE的患病率高达23.69%,表明CRE的出现速度很快。因此,应严格遵守抗生素政策和基本感染控制措施,以减少CRE在社区的传播。
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