Effect of short-term fasting on the expression of ACTH (cMC2) receptor in the adrenal glands of chicken (Gallus domesticus)

Izabela Szpręgiel, D. Wrońska
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Abstract

Domestic hen is a full model in terms of stress and adrenal function. The main hormone produced by the hens’ adrenals is corticosterone, synthesized and secreted by stimulating the HPA axis during stress. Direct activation of adrenal activity is conditioned by ACTH, which binds to the melanocortin receptor cMC2 in adrenals. It stimulates the synthesis and release of corticosterone. One of the factors that stimulate the HPA axis activity is the starvation, to which the hen is very sensitive. The purpose of this study was to determine the ACTH receptor cMC2 expression in the hens’ adrenals during the short-term fasting and after restoring the proper level of nutrition (refeeding). The results of the experiment show that 24-hour of food deprivation is stressful for the hen, as indicated by increased concentrations of corticosterone in the adrenals and in blood plasma. Changes in cMC2R expression and level of corticosterone in the adrenals during fasting and refeeding indicate a rapid increase of HPA axis activity in response to differentiated levels of nutrition. The results of this experiment confirm the direct effect of ACTH on the avian adrenals in corticosterone release.
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短期禁食对家鸡肾上腺ACTH (cMC2)受体表达的影响
家鸡在应激和肾上腺功能方面是一个完整的模型。母鸡肾上腺产生的主要激素是皮质酮,在压力下通过刺激下丘脑轴合成和分泌。肾上腺活性的直接激活是由ACTH调节的,ACTH与肾上腺中的黑素皮质素受体cMC2结合。它刺激皮质酮的合成和释放。刺激HPA轴活动的因素之一是饥饿,母鸡对此非常敏感。本研究的目的是测定短期禁食和恢复适当营养水平(再饲喂)后蛋鸡肾上腺中ACTH受体cMC2的表达。实验结果表明,24小时的食物剥夺对母鸡来说是有压力的,正如肾上腺和血浆中皮质酮浓度增加所表明的那样。在禁食和再喂养期间,肾上腺中cMC2R表达和皮质酮水平的变化表明HPA轴活性在不同营养水平下迅速增加。本实验结果证实了ACTH对鸟肾上腺皮质酮释放的直接影响。
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12 weeks
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