Development of Biopsy Tract Sealants Based on Shape Memory Polymer Foams.

IF 1.1 3区 地球科学 Q2 ANTHROPOLOGY Latin American Antiquity Pub Date : 2023-09-01 Epub Date: 2023-02-08 DOI:10.1007/s44174-023-00064-1
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Abstract

Lung biopsies are often used to aid in the diagnosis of cancers. However, the procedure carries the dual risk of air (pneumothorax) or blood (hemothorax) filling the pleural cavity, increasing the risk of a collapsed lung and chest intubation. This work demonstrates the effectiveness of a polyurethane-based shape memory polymer foam as a biopsy tract sealant. The impact of diameter, length, pore size, and shape memory effect was evaluated to determine the ideal device design for tract sealing. Characterization in an in vitro benchtop lung model identified that diameter had the largest influence on sealing efficacy, while the length of the device had little to no impact. Finally, evaluation of deployment force demonstrated that devices fabricated from the shape memory polymer foams were easier to deploy than elastic foams. Following characterization, down-selected device designs were combined with radiopaque markers for use in image-guided based procedures. Furthermore, the introduction of the markers or sterilization did not impact the ability of the devices to seal the biopsy tract and led to a decrease in the deployment force. Overall, these results demonstrate the potential for polyurethane-based shape memory foam devices to serve as biopsy tract sealant devices that aim to reduce complications, such as pneumothorax, from occurring.

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开发基于形状记忆聚合物泡沫的活检通道密封剂
肺活检通常用于帮助诊断癌症。然而,该手术具有空气(气胸)或血液(血胸)充满胸膜腔的双重风险,增加了肺部塌陷和胸部插管的风险。这项研究证明了聚氨酯形状记忆聚合物泡沫作为活检道密封剂的有效性。评估了直径、长度、孔径和形状记忆效应的影响,以确定理想的活检道密封装置设计。在体外台式肺部模型中进行的特性分析表明,直径对密封效果的影响最大,而装置的长度几乎没有影响。最后,对展开力的评估表明,用形状记忆聚合物泡沫制造的装置比弹性泡沫更容易展开。表征完成后,经过筛选的装置设计与不透射线标记相结合,可用于基于图像引导的手术。此外,标记物的引入或消毒不会影响装置密封活检道的能力,也不会导致展开力下降。总之,这些结果证明了聚氨酯形状记忆泡沫装置作为活检道密封装置的潜力,其目的是减少气胸等并发症的发生。
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CiteScore
2.00
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0.00%
发文量
75
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