Cell-cell communication predicts aging, senescence and death: an integrated, predictive evolutionary approach

J. Torday
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引用次数: 2

Abstract

None of the extant theories of aging have proven to be effective in advancing our knowledge of senescence or mortality. In contrast to the gene-centric focus on evolution, the mechanism of cell-cell interactions as the driving force for evolution as the logic of biology is proposed. Since the distribution of  bioenergy over the course of the life cycle is skewed towards the reproductive phase, bioenergy flags in the post-reproductive stage of life, causing failure of cell-cell signaling, loss of homeostatic control, senescence and death. In the interim, the phenotype acts as the ‘agent’ for epigenetic inheritance, obtaining ‘marks’ that inform the organism of changes in the environment. Such marks are inherited by the offspring, providing it with foreknowledge of the environment to come. The organism appears to ‘return’ to the unicellular state over the course of the life cycle, but in reality meiosis is the mechanism of epigenetic inheritance, the adult phenotype being the means for transmitting the epigenetic marks obtained from the environment back to the organism.
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细胞-细胞通讯预测衰老、衰老和死亡:一种综合的、可预测的进化方法
没有一种现存的衰老理论被证明能有效地提高我们对衰老或死亡的认识。相对于以基因为中心的进化,细胞-细胞相互作用的机制作为进化的驱动力作为生物学的逻辑被提出。由于生物能源在整个生命周期中的分布向生殖阶段倾斜,生物能源在生命的后生殖阶段消失,导致细胞-细胞信号传导失败,失去稳态控制,衰老和死亡。在此期间,表现型充当表观遗传的“代理人”,获得“标记”,通知生物体环境的变化。这些标记由后代遗传,使其对未来的环境有预知能力。生物体在整个生命周期中似乎“回归”到单细胞状态,但实际上减数分裂是表观遗传的机制,成年表型是将从环境中获得的表观遗传标记传递回生物体的手段。
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