Cytokine profile in adolescent children with recurrent infections and polypous rhinosinusitis, ways of their correction

Abstract

A brief review of studies on one of the topical issues of otorhinolaryngology - polypous rhinosinusitis in people with recurrent infections is given.It was noted that patients with polyposis rhinosinusitis are more often committed to acute respiratory infections than those without nasal polyposis and they have a significant immunological imbalance.Serum levels of IL-8, IL-1, anti-inflammatory IL-4 and IFN- production were examined in 48 frequently ill patients with a history of respiratory allergopathology and polypous sinusitis.All patients, according to clinical recommendations, received complex conservative therapy.The control group consisted of 21 people who had respiratory infections no more than one or two times during the year and a history that was not aggravated by polypous rhinosinusitis.As a result, a significant decrease in IFN- levels and an increase in the concentrations of IL-8, IL-1, and IL-4 were revealed, which in turn confirms a violation of the body's immunoreactivity, a decrease in local and systemic immunity in patients with recurrent infections and polypous rhinosinusitis.The results obtained predetermine the need for the use of immunocorrective measures in the complex therapy of these patients.