Novel Formulation for Treatment of Mouth Ulcer

Abstract

Mouth ulcer also known as cankers ulcer are normally small painful abscess that can develop in your mouth or the base of your gum due to these we feel uncomfortable in eating, drinking and talking. Women’s, adolescent and people with a family history of mouth ulcers are higher risk for developing mouth ulcer. There is no major drug therapy required for treatment of mouth ulcer, usually people prefer home remedies. But it is not convenient to take , dose variation may occur because there is no definite quantity given, and also it is unpleasant sometimes irritable thus accordingly we formulate candy like formulation that is lozenges which composed of herbal ingredient like, guava leaves , pigeon pea leave, Tulsi, mint, turmeric, liquorice, clove binded with dextrose , which is convenient for patient The prepared lozengesare evaluated for stability parameter, according to ICH Guideline, the improved formulative lozenges where evaluated for physical characters and results comes under pharmacopeial limit. In-vitro dissolution study show’s 90 % drug release within 30 minutes, the stability studies shows that formulation is stable for last 3 months. Here antimicrobial activity of lozenges is also studied and it shows the positive result for topical application. From recent work it was assured that the herbal lozenges can be considered as a reliable delivery system for the treatment of mouth ulcer.