Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00039
Lakshmidevi Sigatapu, S. Sundar, K. Padmalatha, Sravya. K, D. Ooha, P. Uha Devi
Artificial intelligence (AI) has been developing fleetly in recent times in terms of software algorithms, tackle preparation, and operations in a vast number of areas. In this review, we epitomize the rearmost of operations of AI in biomedicine, including complaint diagnostics, living backing, biomedical information processing, and biomedical exploration. The end of this review is to keep track of new scientific accomplishments, to understand the vacuity of technologies, to appreciate the tremendous eventuality of AI in biomedicine, and to give experimenters in affiliated field’s alleviation. It can be asserted that, just like AI itself, the operation of AI in biomedicine is still in its early stage. New progress and improvements will continue to push the frontier and widen the compass of AI operations, and fast developments are envisaged in the near future.AI in healthcare is an umbrella term to describe the application of machine learning (ML) algorithms and other cognitive technologies in medical settings. In the simplest sense, AI is when computers and other machines mimic human cognition, and are capable of learning, thinking, and making decisions or taking actions. Artificial intelligence (AI) is gradationally changing medical practice. With recent progress in digitized data accession, machine literacy and computing structure, AI operations are expanding into areas that were preliminary allowed to be only the fiefdom of mortal experts. In this Review composition, we outline recent breakthroughs in AI technologies and their biomedical applications, identify the challenges for further progress in medical AI systems, and epitomize the profitable, legal and counteraccusations of AI in healthcare.
{"title":"Artificial Intelligence in Healthcare- An Overview","authors":"Lakshmidevi Sigatapu, S. Sundar, K. Padmalatha, Sravya. K, D. Ooha, P. Uha Devi","doi":"10.52711/2231-5713.2023.00039","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00039","url":null,"abstract":"Artificial intelligence (AI) has been developing fleetly in recent times in terms of software algorithms, tackle preparation, and operations in a vast number of areas. In this review, we epitomize the rearmost of operations of AI in biomedicine, including complaint diagnostics, living backing, biomedical information processing, and biomedical exploration. The end of this review is to keep track of new scientific accomplishments, to understand the vacuity of technologies, to appreciate the tremendous eventuality of AI in biomedicine, and to give experimenters in affiliated field’s alleviation. It can be asserted that, just like AI itself, the operation of AI in biomedicine is still in its early stage. New progress and improvements will continue to push the frontier and widen the compass of AI operations, and fast developments are envisaged in the near future.AI in healthcare is an umbrella term to describe the application of machine learning (ML) algorithms and other cognitive technologies in medical settings. In the simplest sense, AI is when computers and other machines mimic human cognition, and are capable of learning, thinking, and making decisions or taking actions. Artificial intelligence (AI) is gradationally changing medical practice. With recent progress in digitized data accession, machine literacy and computing structure, AI operations are expanding into areas that were preliminary allowed to be only the fiefdom of mortal experts. In this Review composition, we outline recent breakthroughs in AI technologies and their biomedical applications, identify the challenges for further progress in medical AI systems, and epitomize the profitable, legal and counteraccusations of AI in healthcare.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00034
Mahe Alam, K. Javed, MA Jafri
Kundur (oleo-gum-resin of Boswellia serrata Roxb.) is an ingredient in certain Unani formulations used in kidney disorders. Cadmium is potentially a severe nephrotoxin, because cadmium has a biologic half life of more than 30 years. In the present study the effects of Kundur and its methanol soluble (MS) and methanol insoluble (MINS) fractions were investigated on Cadmium chloride induced nephrotoxicity in Albino rats. The animals of group I and II were administered with 1% CMC (1000mgl/kg, p.o.) and the animals of groups III, IV and V were administered with Kundur (1000mg/kg, p.o.), MS (650mg/kg, p.o.) and MINS (350mg/kg, p.o.) respectively for eight days. Animals in group II, III, IV and V were co-administered Cadmium chloride (3mg/kg/bodyweight) from the fourth day to the end of study (eight day). On the 9th day (after 24h s.c. ingestion) blood samples were withdrawal, blood samples centrifuged and serum was separated to measure the concentration of blood urea nitrogen (BUN) and serum creatinine. Albino rats fed with Kundur and MI fraction showed a significant prevention in the rise of serum markers while MS failed to prevent the rise of these serum makers. These results suggest that Kundur (Boswellia serrata Roxb.) and MINS fraction may have potential to reduce the nephrotoxicity in Albino rats.
{"title":"Effect of Oleo-gum-resin of Boswellia serrata Roxb. (Kundur) on Cadmium Chloride Induced Renal Toxicity in Albino rats","authors":"Mahe Alam, K. Javed, MA Jafri","doi":"10.52711/2231-5713.2023.00034","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00034","url":null,"abstract":"Kundur (oleo-gum-resin of Boswellia serrata Roxb.) is an ingredient in certain Unani formulations used in kidney disorders. Cadmium is potentially a severe nephrotoxin, because cadmium has a biologic half life of more than 30 years. In the present study the effects of Kundur and its methanol soluble (MS) and methanol insoluble (MINS) fractions were investigated on Cadmium chloride induced nephrotoxicity in Albino rats. The animals of group I and II were administered with 1% CMC (1000mgl/kg, p.o.) and the animals of groups III, IV and V were administered with Kundur (1000mg/kg, p.o.), MS (650mg/kg, p.o.) and MINS (350mg/kg, p.o.) respectively for eight days. Animals in group II, III, IV and V were co-administered Cadmium chloride (3mg/kg/bodyweight) from the fourth day to the end of study (eight day). On the 9th day (after 24h s.c. ingestion) blood samples were withdrawal, blood samples centrifuged and serum was separated to measure the concentration of blood urea nitrogen (BUN) and serum creatinine. Albino rats fed with Kundur and MI fraction showed a significant prevention in the rise of serum markers while MS failed to prevent the rise of these serum makers. These results suggest that Kundur (Boswellia serrata Roxb.) and MINS fraction may have potential to reduce the nephrotoxicity in Albino rats.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00035
Arpita Tupe, S.D. Mankar
Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly water soluble drugs show major problems for drug formulation. Many conventional methods exist to address the issues of poor solubility and bioavailability, but they have many drawbacks. Nanotechnology is employed to address the issues related to these traditional methods for improving solubility and bioavailability. Pharmaceutical nanosuspension is a very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1µm, without any matrix material, stabilised by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through various routes of administration such as oral, topical, parenteral, ocular and pulmonary routes. This article covers the advantages, disadvantages, properties, preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, evaluation, and their drug delivery applications.
{"title":"Nanosuspension: A Novel Approach to Improve the Solubility, Bioavailability and Pharmacokinetics of Poorly Soluble Drugs","authors":"Arpita Tupe, S.D. Mankar","doi":"10.52711/2231-5713.2023.00035","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00035","url":null,"abstract":"Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly water soluble drugs show major problems for drug formulation. Many conventional methods exist to address the issues of poor solubility and bioavailability, but they have many drawbacks. Nanotechnology is employed to address the issues related to these traditional methods for improving solubility and bioavailability. Pharmaceutical nanosuspension is a very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1µm, without any matrix material, stabilised by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through various routes of administration such as oral, topical, parenteral, ocular and pulmonary routes. This article covers the advantages, disadvantages, properties, preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, evaluation, and their drug delivery applications.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In today's societies, Alzheimer's disease (AD) is a significant issue. In the US, more than five million people, most of whom are 65 or older, suffer from Alzheimer's disease. By 2060, there will be fourteen million Americans living with Alzheimer's disease, according to a report by the Alzheimer's Association. To find hits with polypharmacological activities, libraries of compounds can be biologically screened based on these targets. These hits can have their structural properties altered to improve the overall profile, just like molecules created using techniques based on knowledge or medicinal chemistry. Designing multi-target ligands against key targets of interest would undoubtedly benefit from knowledge of the roles played by various targets in the development of AD as well as pharmacophores with related biological activities. Computational tools are used to assist in the design of potential polypharmacological lead molecular scaffolds, in addition to knowledge-based and biological screening-based approaches. It is becoming more common to use pharmacophore modelling, machine learning, and structure-based virtual screening to forecast biological activity and target-ligand interaction for various chemical libraries.
{"title":"Prospective Current Novel Drug Target for the Identification of Natural Therapeutic Targets for Alzheimer's Disease","authors":"Kaman Kumar, Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh","doi":"10.52711/2231-5713.2023.00030","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00030","url":null,"abstract":"In today's societies, Alzheimer's disease (AD) is a significant issue. In the US, more than five million people, most of whom are 65 or older, suffer from Alzheimer's disease. By 2060, there will be fourteen million Americans living with Alzheimer's disease, according to a report by the Alzheimer's Association. To find hits with polypharmacological activities, libraries of compounds can be biologically screened based on these targets. These hits can have their structural properties altered to improve the overall profile, just like molecules created using techniques based on knowledge or medicinal chemistry. Designing multi-target ligands against key targets of interest would undoubtedly benefit from knowledge of the roles played by various targets in the development of AD as well as pharmacophores with related biological activities. Computational tools are used to assist in the design of potential polypharmacological lead molecular scaffolds, in addition to knowledge-based and biological screening-based approaches. It is becoming more common to use pharmacophore modelling, machine learning, and structure-based virtual screening to forecast biological activity and target-ligand interaction for various chemical libraries.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00032
Rutuja R Shah, Rahul S Adnaik, Pratibha R Adnaik, Swapnil S Patil
The major objective of the present investigation was to extract a natural polymer (okra mucilage) with its characterization as a pharmaceutical binder and to formulate, develop and evaluate the compression of tablet using okra binder. Binders are agent employed to impart cohesiveness to the granules. This ensures the tablet remain intact after compression. The researcher is trying to find new excipient for potential use of binding agent in tablet formulation continues to the interest. This is because different binding agent can be useful in achieving various tablet mechanical strength and drug release properties for different pharmaceutical purpose. The result presented here shows that the mucilage obtained from okra can be used as a binder in paracetamol tablets formulation with good physical properties. Tablet of long disintegration times were produced, hence it’s potential in binding and prepare the granule of pharmaceutical formulation.
{"title":"Extraction, Isolation and Characterization of Okra Mucilage, as Potential source of Binder in Tablet","authors":"Rutuja R Shah, Rahul S Adnaik, Pratibha R Adnaik, Swapnil S Patil","doi":"10.52711/2231-5713.2023.00032","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00032","url":null,"abstract":"The major objective of the present investigation was to extract a natural polymer (okra mucilage) with its characterization as a pharmaceutical binder and to formulate, develop and evaluate the compression of tablet using okra binder. Binders are agent employed to impart cohesiveness to the granules. This ensures the tablet remain intact after compression. The researcher is trying to find new excipient for potential use of binding agent in tablet formulation continues to the interest. This is because different binding agent can be useful in achieving various tablet mechanical strength and drug release properties for different pharmaceutical purpose. The result presented here shows that the mucilage obtained from okra can be used as a binder in paracetamol tablets formulation with good physical properties. Tablet of long disintegration times were produced, hence it’s potential in binding and prepare the granule of pharmaceutical formulation.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00031
R. S. Chavan, A. V. Shrirao, N. I. Kochar, A. V. Chandewar
Medicinal plants contain the bioactive compounds which are utilized in old as well as current remedy, unorganized substances and herbal medicines has recently received major attentiveness because of wide range of functions. Although there are modern treatments available everywhere, interest in and uses of herbal remedies have grown significantly in recent years. Seeds, berries, roots, leaves, bark and flowers can all be utilized to make herbal medicine. Herbal medications can be created in the form of an ointment in addition to various dosage forms. A viscous semisolid mixture known as an ointment is applied topically to a range of bodily surfaces. The objective of the existing work is to create and assess the ointment containing an extract of Butea monosperma (Lam.) leaves. The ethanolic extracts were ready by utilizing maceration technique. Phytochemical screening also done. Ointment base were prepared and preparation of ointment was completed by including the decoction in the base through fusion technique and formulation were evaluated for color, odour, pH, spreadability, consistency, diffusion study, solubility and wash ability.
{"title":"Formulation and Evaluation of Butea monosperma (Lam.) Ointment","authors":"R. S. Chavan, A. V. Shrirao, N. I. Kochar, A. V. Chandewar","doi":"10.52711/2231-5713.2023.00031","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00031","url":null,"abstract":"Medicinal plants contain the bioactive compounds which are utilized in old as well as current remedy, unorganized substances and herbal medicines has recently received major attentiveness because of wide range of functions. Although there are modern treatments available everywhere, interest in and uses of herbal remedies have grown significantly in recent years. Seeds, berries, roots, leaves, bark and flowers can all be utilized to make herbal medicine. Herbal medications can be created in the form of an ointment in addition to various dosage forms. A viscous semisolid mixture known as an ointment is applied topically to a range of bodily surfaces. The objective of the existing work is to create and assess the ointment containing an extract of Butea monosperma (Lam.) leaves. The ethanolic extracts were ready by utilizing maceration technique. Phytochemical screening also done. Ointment base were prepared and preparation of ointment was completed by including the decoction in the base through fusion technique and formulation were evaluated for color, odour, pH, spreadability, consistency, diffusion study, solubility and wash ability.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00036
Monika G. Shinde, Kaufiya D. Sayyad, Ganesh V. Swami, Priti B. Savant, Pooja R. Yalmar, Swati T. Mane
Inflammation underlies a wide variety of physiological and pathological processes. The classic instigators of inflammation infection and tissue injury are at one end of a large range of adverse conditions that induce inflammation, and they trigger the recruitment of leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction similarly induces an adaptive response, which is referred to here as Para-inflammation. This response relies mainly on tissue resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases.
{"title":"A Review on Inflammation and its Pharmacotherapy","authors":"Monika G. Shinde, Kaufiya D. Sayyad, Ganesh V. Swami, Priti B. Savant, Pooja R. Yalmar, Swati T. Mane","doi":"10.52711/2231-5713.2023.00036","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00036","url":null,"abstract":"Inflammation underlies a wide variety of physiological and pathological processes. The classic instigators of inflammation infection and tissue injury are at one end of a large range of adverse conditions that induce inflammation, and they trigger the recruitment of leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction similarly induces an adaptive response, which is referred to here as Para-inflammation. This response relies mainly on tissue resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00033
Nirmala D, K Sai Bhavani, M Sudhakar
Present study was aimed to formulation and evaluation of Simvastatin nanoparticles. Simvastatin nanoparticles were prepared by High pressure homogenization method by using lipid (Glyceryl Monostearate), polymer (Chitosan, Sodium Alginate) and surfactant (Tween 80) in the formulation. The prepared nanoparticles were evaluated for particle size, zetapotential, entrapment efficiency, drug excipients compatability studies by FTIR, scanning electron microscopy and invitro release studies. Among all the formulations, The formulation F8 showed particle size 97.47nm, PDI as 0.333, zeta potential -30.60mV and % Entrapment efficiency 85.69%, FTIR studies shown that drug was compatable with excipients, Scanning electron microscopy results shown that particles in the formulation shows moderately spherical in shape and drug release maximum 97.28%. So, formulations F8 showed better sustain the drug release for 12hrs period of time as compared to other prepared formulations, hence drug release kinetics was applied for F8 formulation. Drug release kinetic studies it showed that optimized formulation F8 showed zero order with non-fickian mechanism.
{"title":"Formulation and Evaluation of Simvastatin Nanoparticles","authors":"Nirmala D, K Sai Bhavani, M Sudhakar","doi":"10.52711/2231-5713.2023.00033","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00033","url":null,"abstract":"Present study was aimed to formulation and evaluation of Simvastatin nanoparticles. Simvastatin nanoparticles were prepared by High pressure homogenization method by using lipid (Glyceryl Monostearate), polymer (Chitosan, Sodium Alginate) and surfactant (Tween 80) in the formulation. The prepared nanoparticles were evaluated for particle size, zetapotential, entrapment efficiency, drug excipients compatability studies by FTIR, scanning electron microscopy and invitro release studies. Among all the formulations, The formulation F8 showed particle size 97.47nm, PDI as 0.333, zeta potential -30.60mV and % Entrapment efficiency 85.69%, FTIR studies shown that drug was compatable with excipients, Scanning electron microscopy results shown that particles in the formulation shows moderately spherical in shape and drug release maximum 97.28%. So, formulations F8 showed better sustain the drug release for 12hrs period of time as compared to other prepared formulations, hence drug release kinetics was applied for F8 formulation. Drug release kinetic studies it showed that optimized formulation F8 showed zero order with non-fickian mechanism.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00041
Sidhartha Jyoti Bora, Runa Chakravorty, Payal Das Gupta
As the use of technology can save time and money thereby providing the aid to the pharma sector. Artificial Intelligence is a branch of computer science which deals with the problem solving by the aid of symbolized programming. AI has evolved into a science of problems solving with enormous applications in business, health care and engineering. This article provides insight of the AI used in drug discovery, various tools of AI, AI’s importance in global pharma pricing & market access debates, Application of AI in pharma.
{"title":"The use of Artificial Intelligence in Pharmacy","authors":"Sidhartha Jyoti Bora, Runa Chakravorty, Payal Das Gupta","doi":"10.52711/2231-5713.2023.00041","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00041","url":null,"abstract":"As the use of technology can save time and money thereby providing the aid to the pharma sector. Artificial Intelligence is a branch of computer science which deals with the problem solving by the aid of symbolized programming. AI has evolved into a science of problems solving with enormous applications in business, health care and engineering. This article provides insight of the AI used in drug discovery, various tools of AI, AI’s importance in global pharma pricing & market access debates, Application of AI in pharma.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5713.2023.00037
S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale
While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Despite the fact oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to make easier oral peptide delivery. As well, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonisation and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.
{"title":"Basics and Recent Advances in Peptide and Protein Drug Delivery","authors":"S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale","doi":"10.52711/2231-5713.2023.00037","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00037","url":null,"abstract":"While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Despite the fact oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to make easier oral peptide delivery. As well, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonisation and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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