Cardiorenal Disease in COVID-19 Patients

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2022-03-18 DOI:10.1155/2022/4640788
Muhtasham Sifaat, Pinak Patel, Razan Sheikh, Dawood Ghaffar, Hitesh Vaishnav, Ludmila Nahar, Sonia Rupani, Syed Quadri
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引用次数: 2

Abstract

Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutations in the genetic coding and the variations in the spike proteins are critical for the virus's mechanism of facilitating fusion with the human host, making the disease more severe. Recent research indicates that comorbidities including diabetes, hypertension, renal disease, heart failure, and atherosclerosis play a significant role in the severity and high mortality rates of (COVID-19), suggesting that perhaps the metabolic syndrome and its components are associated with COVID-19 morbidity. Primarily, angiotensin-converting enzyme 2 (ACE2) receptor is identified as the entrance receptor of SARS-CoV-2. Increased ACE2 expression, endothelial dysfunction plays a vital role in the progression and severity of complications developed due to COVID-19. In this review, we will discuss the association and management of cardiorenal disease and COVID-19.
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COVID-19患者的心肾疾病
2019冠状病毒病(COVID-19)是由一种名为严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)的新型冠状病毒引起的疾病。基因编码的突变和刺突蛋白的变异对病毒促进与人类宿主融合的机制至关重要,从而使疾病更加严重。最近的研究表明,包括糖尿病、高血压、肾脏疾病、心力衰竭和动脉粥样硬化在内的合并症在COVID-19的严重程度和高死亡率中起着重要作用,这表明代谢综合征及其组成部分可能与COVID-19的发病率有关。首先,血管紧张素转换酶2 (ACE2)受体被确定为SARS-CoV-2的入口受体。ACE2表达升高、内皮功能障碍在COVID-19并发症的进展和严重程度中起着至关重要的作用。在这篇综述中,我们将讨论心肾疾病与COVID-19的关联和管理。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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