Tritium-Labeled Compounds IX. Determination of Isotope Effects in Reactions Yielding Water-t from Nonvolatile Reactants. Oxidation of Aldoses-1-t With Iodine.
{"title":"Tritium-Labeled Compounds IX. Determination of Isotope Effects in Reactions Yielding Water-<i>t</i> from Nonvolatile Reactants. Oxidation of Aldoses-<i>1</i>-<i>t</i> With Iodine.","authors":"Horace S Isbell, Lorna T Sniegoski","doi":"10.6028/jres.067A.054","DOIUrl":null,"url":null,"abstract":"<p><p>A convenient method is presented for estimating isotope effects in reactions which yield water-<i>t</i>. The water-<i>t</i> is separated by freeze-drying, and <i>k*/k</i> is calculated from the extent of the reaction and the ratio of the radioactivity of the water-<i>t</i> to that of the initial reactant. Application of the method to the oxidation of aldoses-1-<i>t</i> at 25 °C with iodine in alkaline solution gives values for <i>k*/k</i> ranging from 0.12 to 0.17, with an average of 0.14. There are no significant differences in the values of <i>k*/k</i> obtained for aldoses differing in configuration, or for pentoses and hexoses. The isotope effect corresponds to a ratio of one to seven for the respective rates of reaction of the labeled and unlabeled molecules.</p>","PeriodicalId":94340,"journal":{"name":"Journal of research of the National Bureau of Standards. Section A, Physics and chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1963-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322772/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of research of the National Bureau of Standards. Section A, Physics and chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6028/jres.067A.054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"1963/12/1 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A convenient method is presented for estimating isotope effects in reactions which yield water-t. The water-t is separated by freeze-drying, and k*/k is calculated from the extent of the reaction and the ratio of the radioactivity of the water-t to that of the initial reactant. Application of the method to the oxidation of aldoses-1-t at 25 °C with iodine in alkaline solution gives values for k*/k ranging from 0.12 to 0.17, with an average of 0.14. There are no significant differences in the values of k*/k obtained for aldoses differing in configuration, or for pentoses and hexoses. The isotope effect corresponds to a ratio of one to seven for the respective rates of reaction of the labeled and unlabeled molecules.
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