Nuevas estrategias farmacológicas experimentales para la preservación de la fertilidad en tratamiento concomitante con la quimioterapia

Abstract

Chemotherapy is the main treatment in cancer; nevertheless it induces the abnormal activation of primordial follicles that remain quiescent in the ovaries since birth, thus producing early ovarian failure due to the incessant consumption of the ovarian reserve. Some experimental treatments have recently demonstrated how to avoid the primordial follicle consumption, and prevent the loss of follicles during chemotherapy treatment. Although its use has been tested in experimental and controlled studies, more scientific evidence is necessary to demonstrate its applicability in humans. In this review, different drugs in co-treatment with chemotherapy able to preserve fertility in animal models are presented, acting on the primordial follicle activation pathway.