The role and progress of complement activation in antiphospholipid syndrome

Abstract

Antiphospholipid syndrome(APS) is a non-inflammatory autoimmune disease caused by anti-phospholipid antibodies. In recent years, it has been found that over-activation of complement is the key factor leading to the formation of thrombosis and pathological pregnancy in APS. With more understanding of the role of complement activation in the pathogenesis of APS, methods of complement inhibition therapy have emerged one after another. Therefore, the detection of complement components is of great significance for the early diagnosis, treatment and monitoring of APS. Key words: Complement activation; Antiphospholipid syndrome; Complement system proteins; Biomarkers