A. Baitukha, Iman Al-dybiat, Azadeh Valinataj-Omran, J. Pulpytel, M. Pocard, Massoud Mirsha’shi, F. Arefi-Khonsari
{"title":"Low Pressure Plasma Processing of Collagen Membranes for Anti-Cancer Drug Delivery","authors":"A. Baitukha, Iman Al-dybiat, Azadeh Valinataj-Omran, J. Pulpytel, M. Pocard, Massoud Mirsha’shi, F. Arefi-Khonsari","doi":"10.4172/2169-0022.1000499","DOIUrl":null,"url":null,"abstract":"For targeting the cancer cells, a low pressure ICP reactor was utilised to fabricate a drug delivery system. On the surface of biocompatible collagen membranes, thin plasma polymer coatings were deposited to encapsulate an anticancer drug carboplatin and impart different biologically active functionalities. The characteristics of the deposited films were analysed by FTIR and XPS and the overall functionalities were tested by in vitro and in vivo experiments on the cancer cells lines on the cancer nodules respectively. Preliminary results of fabricated drug delivery systems showed the inhibition of cancer cell proliferation in vitro as well as tumour growth in mice models by 2.8 folds in mass compared to the control case","PeriodicalId":16326,"journal":{"name":"Journal of Material Sciences & Engineering","volume":"50 1","pages":"1-6"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Material Sciences & Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2169-0022.1000499","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
For targeting the cancer cells, a low pressure ICP reactor was utilised to fabricate a drug delivery system. On the surface of biocompatible collagen membranes, thin plasma polymer coatings were deposited to encapsulate an anticancer drug carboplatin and impart different biologically active functionalities. The characteristics of the deposited films were analysed by FTIR and XPS and the overall functionalities were tested by in vitro and in vivo experiments on the cancer cells lines on the cancer nodules respectively. Preliminary results of fabricated drug delivery systems showed the inhibition of cancer cell proliferation in vitro as well as tumour growth in mice models by 2.8 folds in mass compared to the control case
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
