Ameliorative effect of vitamin C on cypermethrin-induced hepatotoxicity and renal malfunction of adult male rats.

N. Kheirallah, H. K. Hussein, Horeya Said Abd El Gawad, B. Youssef
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Abstract

Cypermethrin is a widely used insecticide belongs to type II pyrethroids. It is highly used in developing countries to control many species of insects as it plays an important role in pest control. Vitamin C is an important intracellular antioxidant against insecticides. The aim of the present study is to analyze the toxic effects of cypermethrin (CYP) and the positive effect of vitamin C (VC) with graded doses (0 CYP, 200 VC, 12 CYP and 12 CYP+200 VC mg/kg body weight of male rats/day) for 30 days on liver and kidney functions. Moreover, antioxidant enzymes, oxidative stress markers, glycogen and glucose levels and also serum lipid profile were studied. Also, this study aimed to evaluate the possible protective role of vitamin C against cypermethrin toxicity
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维生素C对氯氰菊酯所致成年雄性大鼠肝毒性和肾功能损害的改善作用。
氯氰菊酯是一种广泛使用的杀虫剂,属于II型拟除虫菊酯。它在发展中国家被广泛用于控制许多种类的昆虫,因为它在害虫控制中起着重要作用。维生素C是细胞内抗杀虫剂的重要抗氧化剂。本研究目的是分析氯氰菊酯(CYP)的毒性作用和维生素C (VC)按分级剂量(0 CYP、200 VC、12 CYP和12 CYP+200 VC mg/kg体重/d)连续30 d对雄性大鼠肝肾功能的积极作用。此外,还研究了抗氧化酶、氧化应激标志物、糖原和葡萄糖水平以及血脂水平。同时,本研究旨在评价维生素C对氯氰菊酯毒性的保护作用
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