Study on Prevalence and Severity of Vitamin D Deficiency in Type 2 Diabetic Patients

H. Pandya, D. Patel
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Abstract

Background: The current worldwide epidemic of diabetes mellitus is a serious health problem because of the high toll of vascular complications. Vitamin D deficiency as emerging epidemic have effect on pathophysiology of diabetes mellitus by various mechanisms. Aims: The objectives were to assess the prevalence and severity of vitamin D deficiency in type 2 DM as well as to record the effect of hyperglycaemia on serum vitamin D level. Methods: In this case-control study 70 type 2 diabetic patients were taken as cases and 70 healthy individuals as controls. All participants included in this study were subjected to complete history taking and clinical examination and routine laboratory Investigations were done for all participants. The data was analyse using appropriate statistical tests. Results: The prevalence of low vitamin D level (inclusive of insufficiency and deficiency) was 18.57% in healthy controls, while 84.29% in diabetic group. Mean level of vitamin D in cases was 25.73±7.27 while 34.55±5.17 in healthy population (p value <0.05). Vitamin D deficiency is more seen in uncontrolled diabetes patients. Inverse correlation was recorded between HbA1C and serum vitamin D level (r = - 0.281, p value = <0.001). Conclusions: Vitamin D deficiency is highly prevalent in diabetic patients as compare to normal healthy population. All patients of type 2 Diabetes patients must have screened for serum vitamin D level and if found deficient than it should be treated promptly with vitamin D supplements for better control of hyperglycaemia.
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2型糖尿病患者维生素D缺乏的患病率及严重程度研究
背景:目前糖尿病在世界范围内的流行是一个严重的健康问题,因为它造成了大量的血管并发症。维生素D缺乏作为一种新兴的流行病,通过多种机制对糖尿病的病理生理产生影响。目的:目的是评估2型糖尿病患者维生素D缺乏的患病率和严重程度,并记录高血糖对血清维生素D水平的影响。方法:以70例2型糖尿病患者为病例,70例健康人为对照。本研究的所有参与者均接受了完整的病史记录和临床检查,并对所有参与者进行了常规实验室检查。使用适当的统计检验对数据进行分析。结果:健康对照组维生素D低水平(包括不足和缺乏)患病率为18.57%,糖尿病组为84.29%。正常人群维生素D水平为34.55±5.17 (p值<0.05),正常人群为25.73±7.27 (p值<0.05)。维生素D缺乏在未控制的糖尿病患者中更为常见。HbA1C与血清维生素D水平呈负相关(r = - 0.281, p值<0.001)。结论:与正常健康人群相比,糖尿病患者维生素D缺乏症发生率较高。所有2型糖尿病患者必须筛查血清维生素D水平,如果发现维生素D不足,应及时补充维生素D,以更好地控制高血糖。
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