BioMicroelectromechanical systems: A novel approach for drug targeting in chronic diseases

Pradnya Palekar Shanbhag , Ninadha S. Patil
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引用次数: 4

Abstract

Despite of decades of research in conventional drug delivery systems many challenges are unconfronted in treatment of chronic diseases at a personalized medicine level. So there is a need for development of targeted and efficient drug delivery systems at such levels of treatment. Microelectromechanical systems have some unique characteristics like analyte sensitivity, electrical responsiveness, temporal control and sizes similar to cells and organelles that has led to engineering of implants for drug delivery in various chronic diseases.Targeting can be achieved through the use of this technology as the drugs are released at the site of action as well as in minimal effective concentrations, thus avoiding side-effects also. This review gives a general overview about the Bio Microelectromechanical systems used in targeting with some relevant examples. Hence Microelectromechanical systems prove to be a promising contender for development of drug delivery systems and targeting in pharmaceutical field.

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生物微机电系统:慢性疾病药物靶向治疗的新途径
尽管对传统给药系统进行了数十年的研究,但在个性化治疗慢性疾病方面仍面临许多挑战。因此,有必要在这种治疗水平上开发有针对性和有效的药物输送系统。微机电系统具有一些独特的特性,如分析物敏感性、电响应性、时间控制和与细胞和细胞器相似的大小,这些特性导致了用于各种慢性疾病药物输送的植入物工程。通过使用这种技术可以实现靶向,因为药物在作用部位以最低有效浓度释放,从而也避免了副作用。本文综述了生物微机电系统在靶向治疗中的应用,并给出了相关实例。因此,微机电系统在制药领域的给药系统和靶向研究中具有重要的应用前景。
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Contents Editorial Board Improving disease diagnosis by a new hybrid model Pros, cons and future of antibiotics Abstracts: 5th Annual Congress of the European Society for Translational Medicine (EUSTM-2017), 20-22 October 2017, Berlin, Germany
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