Reaktionen von pyridinium oximen mit dem alkylphosphat dimethoat und seinen derivaten wirkung auf cholinesterasen

Abstract

Reactions of pyridinium oximes with the alkyl phosphate dimethoate and its derivatives. Effects upon cholinesterases

• 1.

  1. Dimethoate (Rogor), a dimethoxydithioalkyl phosphate, does not inhibit the enzymes acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8). An isomerization product (the dithiol derivative) and an oxidation product (the O analogue) may be responsible for observed inhibitory effects. These derivatives are relatively weak inhibitors of cholinesterases.

• 2.

  2. An attempt was made to reactivate the cholinesterases inhibited by these dimethoate derivatives. All the pyridinium oximes employed produced a stronger inhibition of the enzymes, if the concentrations of alkyl phosphate and oxime were high enough.

• 3.

  3. A reaction scheme with a possible explanation for these effects is discussed.