Review on Mucoadhesive Drug Delivery System: Novel Approaches in Modern Era

Abstract

Purpose: This review article has been written with a purpose of providing extensive information regarding the theoretical considerations, mucoadhesive polymers and evaluation of mucoadhesive drug delivery system. It would be beneficial to the researchers working in this field. Approach: The anatomy and physiology of the mucosa is briefly discussed, followed by the elucidation of various theories of mucoadhesion. The properties of various mucoadhesive polymers have been discussed. The potential advantages and disadvantages have also been highlighted. Findings: The success and degree of mucoadhesion is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings. Conclusion: Mucoadhesive drug delivery system offer close contact with the absorption tissue, the mucous membrane, releasing the drug at the site of action leading to an increase in bioavailability and greater local and systemic effects.