{"title":"The chemistry and biology of the anticancer agent, taxol: A review","authors":"K. Pandey, E. Ibezim","doi":"10.4314/JOPHAS.V6I3.48549","DOIUrl":null,"url":null,"abstract":"Taxol, is conceivably the single most essential anticancer drug, today. It was first isolated in exceptionally low yield from the bark of the Western Yew, Taxus brevifolia. The clinical effectiveness of Taxol has impelled an incredible endeavor to obtain this intricate molecule synthetically. Owing to the chemical complication of Taxol, its commercial manufacture by total synthesis is not likely to be economical. The chemical and biological properties, along with mechanism of action of Taxol are discussed here.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2009-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical and Allied Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/JOPHAS.V6I3.48549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Taxol, is conceivably the single most essential anticancer drug, today. It was first isolated in exceptionally low yield from the bark of the Western Yew, Taxus brevifolia. The clinical effectiveness of Taxol has impelled an incredible endeavor to obtain this intricate molecule synthetically. Owing to the chemical complication of Taxol, its commercial manufacture by total synthesis is not likely to be economical. The chemical and biological properties, along with mechanism of action of Taxol are discussed here.
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