Synthesis, characterization and biological activity studies on amide derivatives

Abstract

DOI : 10.26650/IstanbulJPharm.2018.18007 In this study, with intent to find out novel anti-biofilm and antiviral agents, a series of amide  derivatives were synthesized and their structures were elucidated by FT-IR and 1H-NMR and  13C-NMR and MS methods. And also, their purity were proven by TLC, HPLC and elemental  analyses. And finally, the synthesized compounds were examined for their biofilm formation  and swarming motility inhibitory activities in P. aeruginosa PA01. These compounds were  found to reduce biofilm formation by 8.7-25.6% and swarming motility by 18.3-33.8% in P.  aeruginosa PA01 at a concentration of 200 μM. Besides, all of the compounds were evaluated for their antiviral activity against influenza A viruses. The plaque inhibition assays indicated  that compound 6 (N-(4-{[5-(ethylamino)-1,3,4-thiadiazol-2-yl]methyl}phenyl)-4-  fluorobenzamide) has considerable inhibitory effect on influenza A virus plaque formation.