INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS

L. Babinets, I. Halabitska
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Abstract

The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome. The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis. Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA. Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.
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外分泌胰功能不全对2型糖尿病合并原发性骨关节炎患者病程的影响
考虑到慢性胰腺炎(CP)合并2型糖尿病(DM2)和原发性骨关节炎(OA)的患者与代谢综合征的存在相关,对慢性胰腺炎(CP)合并2型糖尿病(DM2)和原发性骨关节炎(OA)患者胰腺功能能力的研究也具有相关性。该研究的目的是研究慢性胰腺炎合并2型糖尿病合并骨关节炎患者胰腺功能的状态。材料和方法。本文对117例CP合并OA合并DM2和不合并DM2的患者进行了研究。主要组为92例处于稳定或不稳定缓解期的CP合并OA合并糖尿病门诊患者,对照组为25例孤立性CP合并原发性OA患者,对照组为30例健康个体。根据普遍接受的诊断标准和方案确定OA、CP和DM2的诊断结果。数据分析显示,平均而言,在研究的OA合并症患者中,CP和胰腺DM2排泄不足明显比孤立CP合并OA患者组更严重。结论。在CP和DM2合并OA的过程中,粪便α-弹性酶-1与糖化血红蛋白的相关性明显强于单独CP组,说明CP和DM2相互加重作用。
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