Investigation of Methamphetamine Effects on the Tissue Structure of the Main Gonadal in Rats

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Abstract

Introduction: Methamphetamine is a stimulant of the central nervous system that is usually misused. This study aimed to determine the effects of methamphetamine on the diameter and thickness of seminiferous tubules of adult male rats’ main gonad. Method: Twenty adult male rats weighted 200 to 220 gr were used in the current study. They were divided into study and control groups, each consisting of 10 rats. The study group received 2 mg per body weight of methamphetamine in the first three days and 5 mg in the next four days in peritoneum. The control group, on the other hand, received 0.5 ml per rat of physiologic serum in the the peritoneum. Twenty-four hours after the last injection, the rats were killed, and the main gonad was taken out of the scrotum. After tissue passage and dying with hematoxylin and eosin, the main gonad was observed with an optic microscope, and the results were analyzed using an independent t-test. A value of P<0.05 was considered to determine the level of significance between the two groups. Results: The findings showed that using methamphetamine significantly decreases the average diameter and thickness of the epithelium of seminiferous tubules of rats. It was also found that the weight of rats and gonads decreased, but it was not statistically significant. Conclusion: The results of this study show that methamphetamine is a poisonous compound for the main gonad of male rats due to the degeneration and atrophy of seminiferous tubules
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甲基苯丙胺对大鼠主要性腺组织结构影响的研究
简介:甲基苯丙胺是一种中枢神经系统的兴奋剂,通常被滥用。本研究旨在探讨甲基苯丙胺对成年雄性大鼠主性腺精小管直径和厚度的影响。方法:选用体重200 ~ 220克的成年雄性大鼠20只。它们被分为研究组和对照组,每组10只。研究组在前三天接受每体重2毫克的甲基苯丙胺,在接下来的四天接受腹膜5毫克的甲基苯丙胺。对照组每只大鼠腹腔灌胃生理血清0.5 ml。最后一次注射24小时后,处死大鼠,将主性腺从阴囊中取出。组织传代、苏木精、伊红染色后,光学显微镜下观察主性腺,采用独立t检验分析结果。P<0.05为两组间差异的显著性水平。结果:甲基苯丙胺显著降低大鼠精小管上皮的平均直径和厚度。还发现大鼠体重和性腺均有所下降,但无统计学意义。结论:甲基苯丙胺是雄性大鼠主要性腺的一种有毒化合物,主要是由于雄性大鼠精小管的退化和萎缩
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