Linezolid use in Medicine Therapy against Multiresistant Bacteria-AReview

N. S. Mendes, M. Costa, T. Paulino, F. Agostinho, M. Ribeiro, R. Paludo, W. Rodrigues, C. B. Miguel
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Abstract

After the description of an element with ability to combat the infectious processes originating from bacteria, starts a race for survival between the interrelationship of species, bacterial and human. With the evolution scientifictechnical, the man was able to synthesize new antibacterial substances, on the other hand the mechanisms of gene evolution enabled the emergence of multidrug-resistant bacteria. Some of this organisms are frequent on hospital environment and have high adaptability to new drugs, such as Staphylococcus aureus and Enterococcus spp. resistant to oxacillin and vancomycin, considered drugs of choice against multidrug-resistant microorganisms. So, a new antibiotics class was developed, superior to vancomycin and oxazolidinone, the linezolid. Thus, the present study aimed at understanding the use of linezolid in drug therapy against multi-resistant bacteria. To perform this study, a literature review of last 10 years was performed. In 2002, after the liberation of the use of linezolid as treatment for infectious processes against gram-positive bacteria, this drug was commonly used throughout the world. Similarly, the pressure of natural selection stood out, and there were records of resistant strains to linezolid. As prospects for control of infections caused by these resistant strains, was approved by the FDA in 2014 the use of drugs with linezolid resistant anti-strains activity. However, we conclude that, in addition to natural selection and genetic variation process, human behavior regarding the use of antibiotics, increases the selection of resistant microorganisms to antibiotic, including linezolid.
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利奈唑胺在多重耐药细菌药物治疗中的应用综述
在描述了一种能够对抗细菌感染过程的元素之后,开始了一场物种间的生存竞赛,细菌和人类。随着科学技术的进化,人类能够合成新的抗菌物质,另一方面,基因进化的机制使多重耐药细菌的出现成为可能。其中一些微生物常见于医院环境,对新药具有较高的适应性,如耐氧西林和万古霉素的金黄色葡萄球菌和肠球菌,被认为是对抗多重耐药微生物的首选药物。因此,开发了一种优于万古霉素和恶唑烷酮的新型抗生素——利奈唑胺。因此,本研究旨在了解利奈唑胺在多重耐药细菌药物治疗中的应用。为了进行这项研究,我们进行了近10年的文献回顾。2002年,利奈唑胺作为治疗革兰氏阳性菌感染过程的药物得到解放后,这种药物在世界各地得到普遍使用。同样,自然选择的压力也很突出,有对利奈唑胺产生抗性的菌株的记录。由于具有控制这些耐药菌株引起的感染的前景,FDA于2014年批准使用具有利奈唑胺耐药抗菌株活性的药物。然而,我们得出结论,除了自然选择和遗传变异过程外,人类使用抗生素的行为增加了抗生素耐药微生物的选择,包括利奈唑胺。
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