Essential Oil from Nigella Sativa Seed Differentially Ameliorates Steroid Genesis, Cellular ATP and Prostate Functions in Anti-Psychotic Drug- Induced Testicular Damage of Rats

Abstract

Haloperidol is basically employed in combating mental disorder but its usage is controlled because of its adverse effects in other tissues. This study investigates the differential effects of phenolic compounds from black seed oil on key markers linked to testicular dysfunctions induced by Haloperidol in rat model. The animals were divided into six groups (n=10). Group I was given distilled water while Group II received 15 mg/kg body weight of haloperidol via oral route. Group III, IV and V were pre, co and post-treated with the oil, respectively at therapeutic dose of 150 mg/kg body weight. Lastly, Group VI was treated with black seed oil at dose of 150 mg/kg body weight; for 14 days. The results revealed an increase in 5I-nucleotidase and PACP activities with concomitant decrease of Δ5-3β-HSD, Δ5-17β-HSD and LDH activities in rats induced with haloperidol, followed by systemic oxidative damage and adverse histopathological changes in germinal epithelial cells. Co-treatment is most efficacious in preventing haloperidolinduced testicular damage in rat; followed by post and pre-treatment, respectively.