Metabolism, Distribution and Excretion of 2, 2, 3, 3, 3-Pentafluoropropanol in Rats

Abstract

The elimination and metabolism of 2, 2, 2, 3, 3-pentafluoropropanol (5-FP) were investigated in male and female rats for 7 d after a single oral administration at doses of 4, 40, and 400 mg/kg. 5-FP glucuronide and 2, 2, 3, 3, 3-pentafluoropropionic acid (5-FPA) as major metabolites were determined by head-space analysis using GC-MS in the selected ion monitoring-mode. 5-FP glucuronide and 5-FPA were found in urine and feces of both male and female rats. The cumulative excretion of 5-FP in the urine was 28.6-59.3% of the dose and only 0.46-1.28% in the feces in both sexes. A sex-related difference in urinary excretion of 5-FPA was observed in the two dose levels (4 and 40 mg/kg). The recoveries of 5-FPA in the urine of rats administered 5-FP were 10.7-11.9% in male and 33.0-38.2% in female by 7 d post treatment. The sex-related difference of biological half-lives (t1/2) were also observed in some tissues such as liver, kidney and blood.