Phenolic chelating agents as antidotes for acute uranyl acetate intoxication in mice

Abstract

Nine phenolic chelating agents were examined as antidotes for acute uranyl acetate intoxication. The ability of these compounds to promote survival was determined and the ability of two of them to remove uranium from the liver and kidney was compared with that of Na3 CaDTPA. The most effective compounds of this type in promoting survival were found to be Tiron and p‐aminosalicylic acid, but Tiron was much more effective in decreasing the uranium burden of the liver and kidneys. These compounds exhibit an antidotal action at higher uranium levels than the compounds reported in earlier studies. The compounds all seem to possess a very modest toxicity when administered ip.