Ferhat Riad, B. Noureddine, Merakeb Mohamed Sofiane, Yanat Betitra
{"title":"Anti-inflammatory and analgesic effect of an alkaloid-fixed oil mix from Linumusitatisimum seeds in vivo","authors":"Ferhat Riad, B. Noureddine, Merakeb Mohamed Sofiane, Yanat Betitra","doi":"10.46325/GABJ.V0I0.928","DOIUrl":null,"url":null,"abstract":"Inflammation is an immune response to chemical, physical or biological aggression. The comprehension of the several pro-inflammatory and pro-resolving process may lead to the development of new functional drugs instead of the conventional ones. However, Inflammation reaction is conventionally treated by steroidal and nonsteroidal anti-inflammatory drugs. These medications may be useless because of their side effects. In this study, we aim to evaluate the anti-inflammatory and analgesic effect of alkaloid /fixed oil mixture (AO) from flaxseeds in-vivo. Three doses of AO mix (50, 100 and 200 mg/kg) were used in several anti-inflammatory and analgesic tests. The obtained results had shown that the AO mix presents a potential anti-inflammatory and analgesic activities. These results highlight the therapeutic potential of alkaloids and fixed oils combination. Additionally, to other research, the present study supports the anti-inflammatory and analgesic effects of flax seeds with an original contribution by combining alkaloids and fixed oil from Linumusitatissimum","PeriodicalId":12670,"journal":{"name":"GABJ","volume":"461 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GABJ","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46325/GABJ.V0I0.928","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Inflammation is an immune response to chemical, physical or biological aggression. The comprehension of the several pro-inflammatory and pro-resolving process may lead to the development of new functional drugs instead of the conventional ones. However, Inflammation reaction is conventionally treated by steroidal and nonsteroidal anti-inflammatory drugs. These medications may be useless because of their side effects. In this study, we aim to evaluate the anti-inflammatory and analgesic effect of alkaloid /fixed oil mixture (AO) from flaxseeds in-vivo. Three doses of AO mix (50, 100 and 200 mg/kg) were used in several anti-inflammatory and analgesic tests. The obtained results had shown that the AO mix presents a potential anti-inflammatory and analgesic activities. These results highlight the therapeutic potential of alkaloids and fixed oils combination. Additionally, to other research, the present study supports the anti-inflammatory and analgesic effects of flax seeds with an original contribution by combining alkaloids and fixed oil from Linumusitatissimum