Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study

F. H. Shandiz, Alireza Pasdar, F. Afzaljavan, Zohre Takalluo, M. Mofrad
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引用次数: 1

Abstract

Background: Cervical cancer is a preventable cancer with various risk factors. In this study, we assessed different risk factors involved in invasive cervical cancer in the Northeast of Iran. Methods: In a case-control study, 99 patients with advanced cervical cancer were compared to 102 healthy, normal women. Cervical cancer risk factors were documented for these groups using a questionnaire and available medical notes. Univariate analysis was done for each risk factor, followed by multivariate regression analysis, to evaluate the most powerful risk factors after adjustment. Results: Multivariate model indicated that sexual transmitted diseases (STD) [p<0.001; OR=7.88, 95% CI (2.59-23.93)], age at first intercourse ≤16 [p=0.048; OR=6.22, 95% CI (1.06-36.51)] and age [p=0.001; OR= 1.11, 95% CI (1.04-1.18)] were independently significant risk factors for cervical cancer. Conclusion: According to this survey, the significant influence of major risk factors, including STD, age at first intercourse, and age itself, has been underlined. Moreover, increasing the social knowledge and educating people to prevent highrisk sexual behaviors, HPV testing, and routine use of HPV vaccine, which is nowadays regarded as a preventive measure in cervical cancer, may also be needed to be implemented in our prevention program.
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伊朗东北部宫颈癌的主要危险因素:来自病例对照研究的证据
背景:宫颈癌是一种具有多种危险因素的可预防癌症。在这项研究中,我们评估了伊朗东北部浸润性宫颈癌的不同危险因素。方法:在一项病例对照研究中,99例晚期宫颈癌患者与102例健康正常妇女进行比较。通过问卷调查和现有的医疗记录,记录了这些群体的宫颈癌风险因素。对各危险因素进行单因素分析,再进行多因素回归分析,以评价调整后影响最大的危险因素。结果:多变量模型显示性传播疾病(STD)患病率[p<0.001;OR=7.88, 95% CI(2.59 ~ 23.93)],初次性行为年龄≤16岁[p=0.048;OR=6.22, 95% CI(1.06-36.51)]和年龄[p=0.001;OR= 1.11, 95% CI(1.04-1.18)]是宫颈癌的独立显著危险因素。结论:调查结果显示,性病、初次性行为年龄、年龄本身等主要危险因素对性行为有显著影响。此外,增加社会知识和教育人们预防高危性行为,HPV检测和常规使用HPV疫苗,这是目前被认为是宫颈癌的预防措施,也可能需要在我们的预防计划中实施。
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16
审稿时长
12 weeks
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