A Comparison Study of Nonanoic Acid and Sodium Lauryl Sulfate in Skin Irritation

Cheol Heon Lee, H. W. Kim, Hee-jin Han, C. Park
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引用次数: 2

Abstract

The cutaneous response to irritants can be influenced by various factors including the characteristic of irritants, the mode of exposure, environmental and host-related factors. It has been suggested that irritants can be divided into two types: corrosive and noncorrosive. Sodium lauryl sulfate (SLS) has been considered as a typical corrosive irritant and nonanoic acid (NAA) an example of a noncorrosive irritant. We applied SLS and NAA solutions on the volar forearm skin for 24 h and measured transepidermal water loss (TEWL) and erythema indices to evaluate some differences in the profile of irritant reaction and skin functions between corrosive and noncorrosive irritation. In our study of TEWL measurements, SLS solutions caused higher TEWL values than NAA solutions, and the slope of the SLS curve was steeper than that of the NAA curve in relation to the concentrations of SLS and NAA. There was a tendency for the TEWL values to plateau at higher NAA concentrations. In the study of the time course of TEWL and erythema indices, TEWL values returned to baseline after 3 weeks in areas patch-tested with 50% NAA, but they did not recover baseline values until 3 weeks in the corresponding areas tested with 5% SLS. However, both SLS and NAA solutions showed a very similar pattern of erythema indices. Our data suggest that skin injuries induced by SLS might need a more prolonged recovery time for TEWL than NAA injuries. SLS, the corrosive irritant, showed a different pattern of cutaneous functional change compared with NAA, the noncorrosive irritant. NAA could also be considered as one of the model irritants in a study of irritant contact dermatitis using a noncorrosive irritant.
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壬酸与十二烷基硫酸钠对皮肤刺激的比较研究
皮肤对刺激物的反应可受到多种因素的影响,包括刺激物的特性、暴露方式、环境和宿主相关因素。有人建议,刺激物可分为两类:腐蚀性和非腐蚀性。十二烷基硫酸钠(SLS)被认为是一种典型的腐蚀性刺激物,而壬酸(NAA)则被认为是一种非腐蚀性刺激物。我们将SLS和NAA溶液应用于前臂掌侧皮肤24小时,并测量经皮失水(TEWL)和红斑指数,以评估腐蚀性和非腐蚀性刺激在刺激反应和皮肤功能方面的一些差异。在我们的TEWL测量研究中,SLS溶液的TEWL值高于NAA溶液,SLS曲线与SLS和NAA浓度的关系斜率比NAA曲线陡。在NAA浓度较高时,TEWL值趋于平稳。在TEWL和红斑指数的时间过程研究中,用50% NAA贴片测试的区域TEWL值在3周后恢复到基线值,而用5% SLS测试的相应区域TEWL值直到3周后才恢复到基线值。然而,SLS和NAA溶液的红斑指数模式非常相似。我们的数据表明,SLS引起的皮肤损伤可能比NAA损伤需要更长的TEWL恢复时间。与非腐蚀性刺激物NAA相比,腐蚀性刺激物SLS表现出不同的皮肤功能改变模式。NAA也可以被认为是使用非腐蚀性刺激物研究刺激性接触性皮炎的模型刺激物之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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