Pharmacological correction of the pathogenesis and symptoms of osteoarthritis of the knee

IF 6.3 1区 医学 Q1 DERMATOLOGY Burns & Trauma Pub Date : 2023-09-04 DOI:10.22141/1608-1706.2.24.2023.946
V.V. Shtroblya, S.S. Philip, S.M. Drogovoz
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Abstract

Background. Osteoarthritis of the knee (OAK) causes severe pain and sometimes disability, which reduces the quality of life and work capacity of patients. Today, the prevalence of OAK is increases; therefore, the development of methods for its treatment and the use of means that slow down or stop the progression of OAK are relevant. Since OAK is a slowly progressive disease, the search for effective drugs with minimal toxicity and a long-lasting effect, which prevent the destruction of articular cartilage and improve the working conditions of the patient, is ongoing. Thus, the main goals of OAK treatment are to reduce symptoms and slow the progression of the disease, which can reduce the negative impact of OAK on the patient’s functional capacity, as well as improve quality of life. OAK is characterized by the progressive destruction of the articular cartilage, especially when it bears a load. In the joint, cartilage aggrecan is the main structural component that provides hydrophilicity and allows to withstand compression loads. Aggrecan is a complex of proteoglycans with hyaluronic acid and is characterized by a high content of chondroitin sulfate chains, while proteoglycan consists of protein and glycosaminoglycan chains (the precursor of the latter is glucosamine). 
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膝关节骨关节炎发病机制和症状的药物纠正
背景。膝关节骨关节炎(OAK)会引起严重疼痛,有时会导致残疾,从而降低患者的生活质量和工作能力。今天,橡树病的流行率正在上升;因此,发展治疗方法和使用减缓或阻止OAK进展的手段是相关的。由于OAK是一种缓慢进展的疾病,因此正在寻找毒性最小且效果持久的有效药物,以防止关节软骨的破坏并改善患者的工作条件。因此,OAK治疗的主要目标是减轻症状和减缓疾病的进展,这可以减少OAK对患者功能能力的负面影响,并改善生活质量。骨性关节炎的特点是关节软骨的进行性破坏,特别是当它承受负荷时。关节、软骨aggrecan是主要的结构组件,提供了亲水性和允许承受压缩载荷。聚集蛋白是蛋白聚糖与透明质酸的复合物,其特点是硫酸软骨素链含量高,而蛋白聚糖由蛋白质和糖胺聚糖链组成(后者的前体是葡萄糖胺)。
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来源期刊
Burns & Trauma
Burns & Trauma 医学-皮肤病学
CiteScore
8.40
自引率
9.40%
发文量
186
审稿时长
6 weeks
期刊介绍: The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.
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