Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Abstract

In the present work an attempt has been made to design the antibiotic drug loaded carbopol-poly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31 g/g of polymer film.The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models.Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm-2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.