Does Solfinacin solve the urgency symptoms in postpartum women ?

Abstract

Background: It is widely accepted that antimuscarinics are considered first-line treatment for patients with overactive bladder (OAB). However, the mechanism by which antimuscarinics improve the symptoms of OAB remains to be fully elucidated.Patients and methods: This study is a clinical prospective follow up study carried out in Consultancy Clinic of Al-Elwiya Maternity Teaching Hospital in Baghdad-Iraq. duration(November, 2019-April, 2020). inclusion criteria were adult postpartum women at childbearing age with symptoms of overactive bladder treated by Gynecologist with Solifenacin tablets. Results:current study showed 34% of them were in age group 20-29 years. Mean parity history of women with OAB was (3); 32% of them had parity history of 1-3 para and 68% of them had parity history of 4-6 para. delivery mode for 84% of women with OAB was vaginal delivery, as well as 36% of women with OAB had ≤7 times of urinations at day, as well as a significant decline in score 2 observed after treatment with Solifenacin (p=0.01). No significant differences were observed in score 3 before and after Solifenacin treatment (p=0.06). A significant decline in score 4 was observed after treatment with Solifenacin (p=0.001). No significant differences were observed in women with OAB before and after Solifenacin treatment, soa highly significant increase in control of urination after treatment (p<0.001). Conclusion: solifenacin drug is effective in reduction of overactive bladder syndrome score three months after treatment. Journal of University of Shanghai for Science and Technology ISSN: 1007-6735 Volume 23, Issue 6, June 2021 Page -375 keywords:solifenacin ,overactive bladder syndrome , after treatment. ةصلاخلا ةذبن ناك .ىودع دوجو مدع عم لوبلا سلسو لوبتلا ةرثكو يلوبلا حاحللإاب اًیریرس ةناثملا طاشن طرف زیمتت : .اھتایح ةیعونو ةأرملا ةحص ىلع ریبك ءبع طاشنلا ةطرفملا ةناثملل ةساردلا فدھ طاشن طرف ضارعأ نم نوناعی نیذلا ةدلاولا دعب تاغلابلا ءاسنلل نیسانیفیلوس جلاع ةیلاعف مییقت : .ةناثملا ثحبلا قرطو ىضرملا يمیلعتلا ةیولعلا ىفشتسمل ةیراشتسلاا ةدایعلا يف تیرجأ ةیریرس ةیلبقتسم ةعباتم ةسارد : نم ةرتفلا لاوط رھشأ ةتس للاخ قارعلا دادغب يف ةموملأل 1 ربمفون 2019 ىتح 30 لیربأ 2020 ةنیع ىلع نم 50 دمتعی نیسانیفیلوس جلاع مییقت ناك .نیسانیفیلوسب ةجلاعملا ةناثملا طاشن طرف عم ةدلاولا دعب ةغلاب ةأرمأ .جلاعلا دعبو لبق ةناثملا طاشن طرف ضارعأ جئاتن سایق ىلع ا جئاتنل ) نیسانیفیلوسلا جلاع لبق ةناثملا طاشن طرف ضارعأ رایعم ةجیتن لیجست مت : (7.6 جلاعلا دعب ) ىلإ نیسانیفیلوسـب 5.6 ) امھنیب ریبكوزیمتم يئاصحا قرف دوجو عم ( P <0.001 ـل جلاعلا رمتسا .( 84 نم ٪ ـل فقوت امنیب ، ةطرفملا ةناثملاب تاباصملا ءاسنلا 16 ـل جلاعلل ةدیج ةباجتسا تظحولو .نھنم ٪ 88 ءاسنلا نم ٪ ـل ةفیعض ةباجتسا تظحول امنیب ، طاشنلا ةطرفملا ةناثملاب تاباصملا 12 جلاعل ةیبناج راثآ تظحول .نھنم ٪ يف نیسانیفیلوس 16 ، مفلا فافج ةعئاشلا ةیبناجلا راثلآا تناك .طاشنلا ةطرفملا ةناثملاب تاباصملا ءاسنلا نم ٪ .ةیؤرلا حوضو مدعو ، كاسملإاو تاجاتنتسلاا ةمزلاتمب تاباصملا ءاسنلا جلاع يف نمآو لاعف ءاود وھ نیسانیفیلوسلا نیراكسملل داضملا لماعلا : .ةناثملا طاشن طرف : ةیحاتفملا تاملكلا نیسانیفیلوس , .ةناثملا طاشن طرف ةمزلاتم رھشا ثلاث دعب جلاعلا